Term
| 2 major intracellular compartments |
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Definition
1. cytosol
2. vesicular system |
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Term
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Definition
-internal contents of the cell
-communicates with the nucleus
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Term
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Definition
-endoplasmic reticulum
-golgi apparatus
-endosomes
-lysosomes, phagosomes, phagolysosomes
-other vesicles |
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Term
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Definition
degraded in- cytosol
peptides bind to - MHC-I
presented to- effector CD8 T cells
effect on presenting cell- cell death |
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Term
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Definition
degraded in- endocytic vesicles (acidification)
peptides bind to- MHC-II
presented to- effector CD4 T cells
effect on presenting cell- activation to kill intravesicular bacteria and parasites |
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Term
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Definition
-formed in lumen of ER
-peptides transported from cytosol to ER
-proteins degraded by proteasomes into peptides
-TAP is gateway from cytosol to ER lumen and MHC binding cleft
-tapasin stabilized MHC
-MHC must bind peptide to cleft to become stable
-transported to cell surface via golgi apparatus |
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Term
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Definition
| -a protein generated to prevent peptide transport through TAP |
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Term
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Definition
-immune cells
-peptides generated in acidified vesicles (not proteasomes)
-join with vesicles containing MHC-II
-binding cleft held by CLIP until peptide is inserted
-HLADM releases CLIP and allows for peptide binding
-present to CD4 helper cells
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Term
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Definition
-cluster of 200 genes
-function: to bind pathogen peptide fragments to display to T cells
-diversity by polygeny and polymorphism |
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