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Definition
| When the immune system either over reacts or fails to recognize "self v non self" |
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| Occurs when an individual's immune system reacts against antigens on the tissues of other members of the same species. |
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| An antibody that has an affinity for certain kinds of cells, in addition to and unrelated to its specific affinity for the antigen that induced it, because of the properties of the Fc portion of the heavy chain |
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Definition
| Deleterious effects of hypersensitivity to environmental antigens |
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| When antibodies fail to recognize self, and form against the basement membrane of kidney or lung. Can result in renal failure and/or lung damage. Usually occurs in 45 y/o Males. |
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| An allergic reaction to an injection of serum, typically mild and characterized by skin rashes, joint stiffness, and fever |
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| A rash of round, red welts on the skin that itch intensely, sometimes with dangerous swelling, caused by an allergic reaction, typically to specific foods |
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Definition
| A noncontagious acute fever marked by inflammation and pain in the joints. It chiefly affects young people and is caused by a streptococcal infection |
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Definition
| A type of SCID (sever combined immune deficiency syndrome), where there is failure to make T cells due to failure of the thymus to develop. Therefore B cells do not get activated. |
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Definition
| Inability to undergo isotype switching- only IgM antibodies. This syndrome is not fatal. |
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Definition
| Descriptions of the 4 types of Hypersensitivity |
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Definition
| Type II hypersensitivity is tissue specific. A heterogenetic antigen with organ specificity; for example, in addition to species-specific antigen, kidney of one species contains antigen that is identical to that in kidney of other species. |
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Term
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Definition
| Type III hypersensitivity disorders form immune complexes. It is the formation of an antibody to an antigen. E.g Lupus and Raynaud phenomenon form antigen/antibody complexes |
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| Cell-mediated hypersensitivity |
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Definition
| Type IV hypersensitivity reactions are inappropriate or excessive immune reactions that are mediated by a specific subsets of CD4 helper T cells or by CD8 cytotoxic T cells. |
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Term
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Definition
| The prevention or reduction of immediate hypersensitivity by administration of graded doses of allergen |
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Term
| Systemic Lupus Erythematosus (SLE or Lupus) |
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Definition
| Circulating antigen-antibody complexes that are deposited on various tissues, results in various responses depending on where the deposition of antibody-antigen complex is. |
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Term
| Bruton's agammaglobulinemia |
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Definition
| The mature B cell does not become immuno competent and is not able to make antibodies. |
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Definition
| Severe Combined Immune Deficiency Syndrome. Inability to make T cells or B cells. |
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Definition
| The system of immune responses of an organism against its own cells and tissues. Any disease that results from such an aberrant immune response is termed an autoimmune disease. |
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Definition
| Type I Hypersensitivity in which an acute allergic reaction to an antigen (e.g. a bee sting) to which the body has become hypersensitive. |
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| Type II Hypersensitvity. The immune system makes too many antibodies that cause the thyroid gland to grow. Results in swelling of the neck and protrusion of the eyes due to an overactive thyroid gland |
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Definition
| Results from Type III Hypersensitivity Raynaud phenomenon. The antibodies form complexes in the cold that are called Cryoglobulins. |
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Definition
| A form of allergy in which a hypersensitivity reaction such as dermatitis or asthma may occur in a part of the body not in contact with the allergen |
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Term
| Immunologically privileged sites |
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Definition
| Certain sites of the human body have immune privilege, meaning they are able to tolerate the introduction of antigens without eliciting an inflammatory immune response. |
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Definition
| A rejection that usually develops immediately after the implantation of a vascular graft; may be caused by preformed, cytotoxic antibodies to the graft; |
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Definition
| Common primary immune deficiency. Individuals are able to produce other classes of Immunoglobulins for fail to produce IgA. Many people are asymptomatic; it is not a sever disorder, may cause minor GI issues. |
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Definition
| A rare autosomal recessive disorder that arises from a mutation of a lysosomal trafficking regulator protein, which leads to a decrease in phagocytosis. The decrease in phagocytosis results in recurrent pyogenic infections, partial albinism and peripheral neuropathy. |
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