Term
|
Definition
-selectins
-integrins
-immunoglobulin superfamily |
|
|
Term
|
Definition
-on endothelial cells
-sialyl-lewis ligan, on neutrophils
-weak binding slows down neutrophil |
|
|
Term
|
Definition
-on leukocytes
-tight binding to intercellular adhesion molecules (ICAM's) on endothelial cells |
|
|
Term
| Acute phase innate immune response proteins |
|
Definition
|
|
Term
| Acute phase protein functions |
|
Definition
-activate the liver to produce more acute phase proteins
-activate bone marrow to release neutrophils
-raise body temperature (bacterial and viral replication less efficient, adaptive immune response works better)
-stimulates dedritic cell migration and maturation into antigen presenting cells |
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|
Term
|
Definition
| -induces production of interferons: IFN-a, IFN-b |
|
|
Term
| three main functions of interferon |
|
Definition
-induce resistance to viral replication
-induce MHC class I expression
-activate NK cells |
|
|
Term
| Natural Killer cells (NK) |
|
Definition
-made in bone marrow
-part of innate immune system because not antigen specific
-"non activated" recognize cells via pattern recognition (virus) or malignantly transformed (cancer)
-ability to kill amplified when exposed to IFN-a, IFN-b, or IL-12
-if does NOT detect MHC1, activated to kill cell
-releases granule content and causes apoptosis |
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|
