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Lecture 38+39- Thyroid+Parathyroid
pharm
15
Pharmacology
Graduate
11/11/2011

Additional Pharmacology Flashcards

 


 

Cards

Term
Levothyroxine
Definition

synthetic T4

Used to treat hypothyroidism

Term
131 Iodine
Definition

-used to treat hyperthyroidism

kills off thyroid gland because it has highest affinity for iodine

Term
Propylthiouracil
Definition

inhibits thyroid hormone synthesis

DOES NOT inhibit release so must wait for storage of hormones to run out

Also blocks conversion of T4 to T3 in periphery

given to make patient euthyroid so 131 Iodine can be given

Term
Methimazole
Definition

inhibits thyroid hormone synthesis

DOES NOT inhibit release so must wait for storage of hormones to run out

given to make patient euthyroid so 131 Iodine can be given

Term
KI (Lugol's Solution)
Definition

5% iodine + 10" potassium iodide

Inhibits thyroid hormone synthesis and release of preformed hormone

given to  kids near power plants

Term
Alendronate
Definition

amino-acid substituted biphosphonate ( more potent than others)

inhibits bone resoprtion without impairing bone mineralization

Used to treat osteoporosis+ Paget's Disease

Major side effect is esophageal erosion

Term
Risedronate
Definition

pyridinal biphosphonate

Used to treat osteoporosis+Paget's Disease

Can cause esophageal erosion

Term
Zoledronate (Reclast)
Definition

Used to treat osteoporosis + Paget's Disease

Administered once a year

Term
Zoledronate (Zometa)
Definition

Used to treat osteoporosis+ hypercalcemia

Administered once a week

Major side effect is osteonecrosis of jaw

Term
Ibandronate
Definition

biphosphonate

used to treat osteoporosis

Taken monthly

Term
Raloxifene
Definition

selective estrogen receptor modulator

approved to treat post menopausal osteoporosis

estrogen agonist in bone and antagonist in breat+uterus

Risk of thromboembolism

Term
Teriparatide
Definition

recombinant form of PTH used to treat osteoporosis

works better than alendronate-greater increase in bone formation in spine+femoral neck

very expensive

Term
Calcitriol
Definition

Most potent vitamin D metabolite

increased Ca absorption and decreased Ca and phoshorus excretion by kidney

Does not depend on liver/kidneys for activation

Used to treat osteoporosis and hypoparathyroidism

Term
Pamidronate
Definition

Amino substituted bisphosphonate

Primarily used for hypercalcemia in malignancy

Term
Calcitonin
Definition

Used to treat hypercalcemia and Paget's Disease

Inhibits osteolysis and prevents abnormal bone formation

Calcimar-from salmon-may not be tolerated by some

Cibacalcin-synthetic human calcitonin-better tolerated

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