Used to treat hypothyroidism

Synthetic T4 which is converted to T3 in effector/peripheral tissues by deiodinase

Must monitor TSH and free thyroxine levels while adminstering drug, dosage less significant

Increase dose if patient pregnant or on estrogen therapy

THIS SHIT IS CHEAP AS HELL YO

Used to treat hyperthyroidism

Drug has short t1/2 allowing for tight control

Emits beta particles, taken up by thyroid and destroys it

No pain or surgery required, easy to use

Don't give to nursing mothers

Also used in the treatment of thyroid cancer

Used to treat hyperthyroidism

Blocks thyroid hormone synthesis by blocking: (1) iodination reaction (2) coupling of iodotyrosines

Doesn't inhibit release of preformed T3/T4

Major Side Effects: Can cause hepatotoxicity and agranulocytosis

For severe disease because it also blocks T4 to T3 conversion in periphery

PTU better for PREGNANT PATIENTS (PPP)

Used to treat hyperthyroidism

Blocks thyroid hormone synthesis by blocking: (1) iodination reaction (2) coupling of iodotyrosines

Doesn't inhibit release of preformed T3/T4

Major Side Effects: Can cause hepatotoxicity and agranulocytosis

Longer t1/2 (6 hrs) than PTU (1.5 hrs)

Can be taken once daily

Can take month for T4/T3 depletion (recall: thyroid gland stores months worth of T4/T3)

Lower risk for agranulocytosis than PTU

Used to treat hyperthyroidism

5% iodine + 10% potassium iodide

Inhibit thyroid hormone synthesis by overloading Iodide transport

Inhibit release of pre-formed/stored hormone

Effects are usually temporary

Treatment of osteoporosis and Paget's Disease

Amino substituted bisphosphate

Inhibits bone resorption without impairing bone mineralization

Increases bone density and reduces fractures

Side effects: GI distress, possible esophageal erosion

Treatment of osteoporosis and paget's disease

Pyridinal bisphosphate - chemically unique

Binds to hydroxyapetite in bone - reduces turnover

Increased bone density and decreased fractures

GI distress, possible esophageal erosion

Need to take with large glass of H2O and sit for 30 mins

Treatment of osteoporosis

Similar to all bisphosphonates

Two dosages: 2.5 mg/day or 150 mg/dose

Side effects: At higher monthly doses, can cause constipation, flu-like symptoms, and pain in extremities

Increased bone mass density with monthly use

Treatment of osteoporosis

Given by injection, concentrate 4 mg / 5 mL, given slowly over 15 mins

After 7 days if blood calcium levels do not decrease, repeat treatment

Osteonecrosis of the jaw especially if given multiple doses

Treatment of osteoporosis

Recall: Parathyroid hormone increases Osteoclast AT LOW DOES (stressed this point)

Recombinant segment of PTH

Postmenopausal osteoporosis in females and males

Adminstered once daily; expensive as hell

Side effects: nausea, dizziness, leg cramps

Works better than alendronate (fosamax)

Treatment of osteoporosis

Recall: Estrogen decreases activity of osteoclasts and increases activity of osteoblasts (GOOD!)

Selective estrogen receptor modulators

Acts as estrogen receptor agonist in bone, antagonist in breast and uterus

Treatment of osteoporosis and hypoparathyroidism

Most potent vitamin D metabolite (1,25 hydroxyvitamin D)

Increases Ca2+ absorption and decreases Ca2+ and phosphorous excretion by kidney

Benefits: reduction in fractures, few side effects, not dependant on liver/kidneys for activation

Treatment of hypercalcemia and Paget's disease

Secreted from parafollicular, lowers Ca2+ by inhibiting osteolysis and increasing Ca2+ excretion by kidney

Treatment of hypercalcemia

Amino substitubed bisphosphonate

Used for hypercalcemia of malignancy (reducing factures in multiple myeloma and metastatic breast cancer)

Side effects: nausea, anorexia, leukopenia, pain at site of injection, expensive