Term
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Definition
Anticholinergic agent
Primary action on vestibular system
Used to treat vertigo & motion sickness
Can cause sedation, confusion, amnesia
Available in transderm preparation (patch) |
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Term
| Diphenhydrinate (Dramamine) |
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Definition
Antihistamine
Primary effect on vestibular system |
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Term
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Definition
Antihistamine
Primary action on vestibular system, but has some weak Effects on CRTZ or vomiting center
Used to treat motion sickness and vertigo, some general antiemetic activity |
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Term
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Definition
Antihistamine
Primary action on vestibular system, but may have some Effect on CRTZ or vomiting center
Used to treat motion sickness and vertigo
May have some general antiemetic activity |
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Term
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Definition
Anthistamine
Primary action on vestibular system
Can have anti-cholinergic side effects |
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Term
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Definition
Dopamine (D2) antagonist
Primary action is at chemoreceptor trigger zone
Used as antiemetic in postop nausea, cytotoxic drugs, radiation sickness, toxins
Can cause parkinsonism, psychomotor slowing, anticholinernergic effects
Can have harmful effects on fetus in preganant mother |
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Term
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Definition
Acts as dopamine antagonist in CRTZ but also on enteric nerves to increase GI tone+motility.
Used in treating nausea+vomiting in cancer chemo, Post-operative nausea
Used to treat GERD and gastric stasis
Used preop to prevent vomiting
Side effects are parkinsonism and sedation |
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Term
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Definition
Serotonin antagonist at 5H-3 receptors
Used for nausea+vomiting in cancer chemo+ post-op
Depresses CRTZ and inhibits serotonin mediated afferent input from GI tract
Can be administered orally or IV
Metabolized by liver
Main side effects are headache+constipation (no parkinsonism) |
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Term
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Definition
Main active ingredient in marijuana
Available in oral filled capsules
Used for N/V in cancer patients who dont respond to other drugs
Used for appetite stimulant in AIDS patients
Side effects are CNS: sedation, confusion, alterated sensation, paranoia (things you feel when you are blazed) |
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Term
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Definition
Newer drug approved for nausea from cancer chemo
Acts as anatagonist at subtype of P/neurokinin receptor (NK1)
Well tolerated but expensive
May be effective in patients who dont respond to other drugs |
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