Adrenergic Bronchodilator

Two effects: (1) bronchodilator (2) inhibit release of autocoids from mast cells

Act quickly; fairly effective in acute attack

Drug of choice in life-threatening anaphylactic reactions and asthmatic bronchospasm

Side effects: CNS stimulation (anxiety, tremors, etc.), cardiac stimulation in patients with CVD, tolerance and rebound bronchoconstriction is a major concern!

Adrenergic Bronchodilator

Two effects: (1) bronchodilator (2) inhibit release of autocoids from mast cells

Act quickly; fairly effective in acute attack

Drug of choice in life-threatening anaphylactic reactions and asthmatic bronchospasm

Side effects: CNS stimulation (anxiety, tremors, etc.), cardiac stimulation in patients with CVD, tolerance and rebound bronchoconstriction is a major concern!

Adrenergic Bronchodilator

Two effects: (1) bronchodilator (2) inhibit release of autocoids from mast cells

Act quickly; fairly effective in acute attack

Drug of choice in life-threatening anaphylactic reactions and asthmatic bronchospasm

Side effects: CNS stimulation (anxiety, tremors, etc.), cardiac stimulation in patients with CVD, tolerance and rebound bronchoconstriction is a major concern!

Adrenergic Bronchodilator

Two effects: (1) bronchodilator (2) inhibit release of autocoids from mast cells

Act quickly; fairly effective in acute attack

Drug of choice in life-threatening anaphylactic reactions and asthmatic bronchospasm

Side effects: CNS stimulation (anxiety, tremors, etc.), cardiac stimulation in patients with CVD, tolerance and rebound bronchoconstriction is a major concern!

Adrenergic Bronchodilator

Two effects: (1) bronchodilator (2) inhibit release of autocoids from mast cells

Act quickly; fairly effective in acute attack

Drug of choice in life-threatening anaphylactic reactions and asthmatic bronchospasm

Side effects: CNS stimulation (anxiety, tremors, etc.), cardiac stimulation in patients with CVD, tolerance and rebound bronchoconstriction is a major concern!

Adrenergic Bronchodilator

Two effects: (1) bronchodilator (2) inhibit release of autocoids from mast cells

Act quickly; fairly effective in acute attack

Drug of choice in life-threatening anaphylactic reactions and asthmatic bronchospasm

Side effects: CNS stimulation (anxiety, tremors, etc.), cardiac stimulation in patients with CVD, tolerance and rebound bronchoconstriction is a major concern!

Adrenergic Bronchodilator

Two effects: (1) bronchodilator (2) inhibit release of autocoids from mast cells

Act quickly; fairly effective in acute attack

Drug of choice in life-threatening anaphylactic reactions and asthmatic bronchospasm

Side effects: CNS stimulation (anxiety, tremors, etc.), cardiac stimulation in patients with CVD, tolerance and rebound bronchoconstriction is a major concern!

Adrenergic Bronchodilator

Two effects: (1) bronchodilator (2) inhibit release of autocoids from mast cells

Act quickly; fairly effective in acute attack

Drug of choice in life-threatening anaphylactic reactions and asthmatic bronchospasm

Side effects: CNS stimulation (anxiety, tremors, etc.), cardiac stimulation in patients with CVD, tolerance and rebound bronchoconstriction is a major concern!

Methylxanthine Bronchodilator

MOA: Increase cAMP thereby stabilizing mast cells

NOT THE PRIMARY EFFECT OF THESE DRUGS

Taken orally in conjuction with other drugs for severe cases of asthma

Narrow therapeutic window, must monitor blood levels of drugs

Side effects: N/V, headaches, insomnia; severe can be cardiac arrhythmias and seizures

Methylxanthine Bronchodilator

MOA: Increase cAMP thereby stabilizing mast cells

NOT THE PRIMARY EFFECT OF THESE DRUGS

Usually given IV for the treatment of severe asthmatic attacks

Narrow therapeutic window, must monitor blood levels of drugs

Side effects: N/V, headaches, insomnia; severe can be cardiac arrhythmias and seizures

Corticosteroid

Inhibit recruitment of leukocytes to sites of inflammation

Inhibit synthesis or release of autocoids

Anti-inflammatory response is useful in treatment of allergies and asthma

Especially useful in asthma where it inhibits CMI against bronchial epithelium (growing reason for use currently!)

Recent developments have allowed corticosteroid use by inhalation, massively useful for asthma patients

Side Effects: Inhaled steroids assoc. with cataracts, cushing syndrome, immune suppresion, osteoporosis, peptic ulcers, growth suppression in children, endocrine dysfunction, reproductive dysfunction

As a result of side effectst, alternate day therapy encouraged

Corticosteroid

Inhibit recruitment of leukocytes to sites of inflammation

Inhibit synthesis or release of autocoids

Anti-inflammatory response is useful in treatment of allergies and asthma

Especially useful in asthma where it inhibits CMI against bronchial epithelium (growing reason for use currently!)

Recent developments have allowed corticosteroid use by inhalation, massively useful for asthma patients

Side Effects: Inhaled steroids assoc. with cataracts, cushing syndrome, immune suppresion, osteoporosis, peptic ulcers, growth suppression in children, endocrine dysfunction, reproductive dysfunction

As a result of side effectst, alternate day therapy encouraged

Corticosteroid

Inhibit recruitment of leukocytes to sites of inflammation

Inhibit synthesis or release of autocoids

Anti-inflammatory response is useful in treatment of allergies and asthma

Especially useful in asthma where it inhibits CMI against bronchial epithelium (growing reason for use currently!)

Recent developments have allowed corticosteroid use by inhalation, massively useful for asthma patients

Side Effects: Inhaled steroids assoc. with cataracts, cushing syndrome, immune suppresion, osteoporosis, peptic ulcers, growth suppression in children, endocrine dysfunction, reproductive dysfunction

As a result of side effectst, alternate day therapy encouraged

Corticosteroid

Inhibit recruitment of leukocytes to sites of inflammation

Inhibit synthesis or release of autocoids

Anti-inflammatory response is useful in treatment of allergies and asthma

Especially useful in asthma where it inhibits CMI against bronchial epithelium (growing reason for use currently!)

Recent developments have allowed corticosteroid use by inhalation, massively useful for asthma patients

Side Effects: Inhaled steroids assoc. with cataracts, cushing syndrome, immune suppresion, osteoporosis, peptic ulcers, growth suppression in children, endocrine dysfunction, reproductive dysfunction

As a result of side effectst, alternate day therapy encouraged

Corticosteroid

Inhibit recruitment of leukocytes to sites of inflammation

Inhibit synthesis or release of autocoids

Anti-inflammatory response is useful in treatment of allergies and asthma

Especially useful in asthma where it inhibits CMI against bronchial epithelium (growing reason for use currently!)

Recent developments have allowed corticosteroid use by inhalation, massively useful for asthma patients

Side Effects: Inhaled steroids assoc. with cataracts, cushing syndrome, immune suppresion, osteoporosis, peptic ulcers, growth suppression in children, endocrine dysfunction, reproductive dysfunction

As a result of side effectst, alternate day therapy encouraged

Corticosteroid

Inhibit recruitment of leukocytes to sites of inflammation

Inhibit synthesis or release of autocoids

Anti-inflammatory response is useful in treatment of allergies and asthma

Especially useful in asthma where it inhibits CMI against bronchial epithelium (growing reason for use currently!)

Recent developments have allowed corticosteroid use by inhalation, massively useful for asthma patients

Side Effects: Inhaled steroids assoc. with cataracts, cushing syndrome, immune suppresion, osteoporosis, peptic ulcers, growth suppression in children, endocrine dysfunction, reproductive dysfunction

As a result of side effectst, alternate day therapy encouraged

Corticosteroid

Inhibit recruitment of leukocytes to sites of inflammation

Inhibit synthesis or release of autocoids

Anti-inflammatory response is useful in treatment of allergies and asthma

Especially useful in asthma where it inhibits CMI against bronchial epithelium (growing reason for use currently!)

Recent developments have allowed corticosteroid use by inhalation, massively useful for asthma patients

Side Effects: Inhaled steroids assoc. with cataracts, cushing syndrome, immune suppresion, osteoporosis, peptic ulcers, growth suppression in children, endocrine dysfunction, reproductive dysfunction

As a result of side effectst, alternate day therapy encouraged

Corticosteroid

Inhibit recruitment of leukocytes to sites of inflammation

Inhibit synthesis or release of autocoids

Anti-inflammatory response is useful in treatment of allergies and asthma

Especially useful in asthma where it inhibits CMI against bronchial epithelium (growing reason for use currently!)

Recent developments have allowed corticosteroid use by inhalation, massively useful for asthma patients

Side Effects: Inhaled steroids assoc. with cataracts, cushing syndrome, immune suppresion, osteoporosis, peptic ulcers, growth suppression in children, endocrine dysfunction, reproductive dysfunction

As a result of side effectst, alternate day therapy encouraged

Corticosteroid

Inhibit recruitment of leukocytes to sites of inflammation

Inhibit synthesis or release of autocoids

Anti-inflammatory response is useful in treatment of allergies and asthma

Especially useful in asthma where it inhibits CMI against bronchial epithelium (growing reason for use currently!)

Recent developments have allowed corticosteroid use by inhalation, massively useful for asthma patients

Side Effects: Inhaled steroids assoc. with cataracts, cushing syndrome, immune suppresion, osteoporosis, peptic ulcers, growth suppression in children, endocrine dysfunction, reproductive dysfunction

As a result of side effectst, alternate day therapy encouraged

Mast Cell Stabilizer

Use: Prophylactic treatment of bronchial asthma (ineffective in acute attack)

MOA: Inhibits release of histamine/autocoids from snesitized mast cells

Has poor absorption from lungs = few systemic effects

Most useful in treatment of extrinsic asthma caused by exposure to specific allergens

Leukotriene Modulator

Cysteinyl leukotriene receptor antagonists

Taken orally to reduce frequency/severity of asthma attacks

Not effective in acute attacks

Approved for treatment of seasonal allergies

Leukotriene Modulator

Cysteinyl leukotriene receptor antagonists

Taken orally to reduce frequency/severity of asthma attacks

Not effective in acute attacks

Leukotriene Modulator

Inhibits lipooxygenase enzyme and decreasing the formation of leukotrienes

P.O. drug to reduce frequency/severity of attacks

No autocoid formation = no autocoid release from Mast cell

Potential for elevated liver enzymes & hepatotoxicity

Antimuscarinic

Prevents bronchospasm caused by ACh (but no others!)

Not as effective as sympathomimetic bronchodilators

Dries secretions = undesirable

Not well absorbed = few systemic effects

Combivent = (ipratropium + albuterol) combination therapy

Antimuscarinic

Prevents bronchospasm caused by ACh (but no others!)

Not as effective as sympathomimetic bronchodilators

Dries secretions = undesirable

Combination products for asthma

(Salmeterol/Fluticasone)

H1 Histamine Antagonist

Use: Treatment of allergic rhinitis/dermatitis

Not that useful in treating bronchoconstriction caused by asthma and anaphylaxis, because many other mediators besides histamine also mediate this response

I.E. Don't know this shit?

H1 Histamine Antagonist

Use: Treatment of allergic rhinitis/dermatitis

Not that useful in treating bronchoconstriction caused by asthma and anaphylaxis, because many other mediators besides histamine also mediate this response

I.E. Don't know this shit?

H1 Histamine Antagonists

Use: Treatment of allergic rhinitis/dermatitis

Not that useful in treating bronchoconstriction caused by asthma and anaphylaxis, because many other mediators besides histamine also mediate this response

I.E. Don't know this shit?

H1 Histamine Antagonists

Use: Treatment of allergic rhinitis/dermatitis

Not that useful in treating bronchoconstriction caused by asthma and anaphylaxis, because many other mediators besides histamine also mediate this response

I.E. Don't know this shit?