Term
| Describe the polarization of the epithelium. Where are PRRs found? |
|
Definition
apical side faces towards commensal bacteria
basolateral side is sterile
PRRs on basolateral side |
|
|
Term
True or False
Keratinocytes are innate immune cells |
|
Definition
|
|
Term
| Describe the epidermis of cartilagenous fish |
|
Definition
| placoid scales protruding from epidermis |
|
|
Term
| Describe the epidermis of bony fish (3) |
|
Definition
-mucus coating w/ antimicrobial peptides
-melanopores for skin pigment & ROS protection
-neural sensory cells along lateral line |
|
|
Term
| Why are keratinocytes important? |
|
Definition
-communicate with skin-associated lymphoid tissue
-maintain tolerance to commensals
-form stratum corneum to protect against UV, abrasion etc |
|
|
Term
| Why is dark skin better at retaining water? |
|
Definition
| thicker stratum corneum, greater lipid content |
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|
Term
| Why would caucasian people be more susceptible to spina bifida if their mother were living in a tropical environment during the pregnancy? |
|
Definition
| UV-induced folic acid depletion |
|
|
Term
| What do sheep secrete from their sebaceous glands? |
|
Definition
|
|
Term
| Why are hoofed animals at greater risk of immune sensitization? |
|
Definition
| sweat glands are localized under axilla, can become sensitive to exposure to haptens which can lead to allergic contact dermatitis |
|
|
Term
| What antimicrobial peptides are found in sweat? |
|
Definition
|
|
Term
| Is allergic contact dermatitis due to cell-mediated hypersensitivity or antibody-mediated? |
|
Definition
|
|
Term
| What secondary lymphoid tissues do epithelial cells of the respiratory tract communicate with? |
|
Definition
NALT & BALT
(nasal & bronchi associated) |
|
|
Term
| What cells secrete surfactants? |
|
Definition
goblet cells
Type 2 pneumocytes |
|
|
Term
| What do Clara cells secrete? |
|
Definition
|
|
Term
| What do microfold cells in the bronchi do? (M cells) |
|
Definition
| take antigens from mucus, pass them to tissue macrophages & dendritic cells for antigen presentation to lymph |
|
|
Term
|
Definition
| the epithelial cells of the alveoli |
|
|
Term
| What do Type 2 pneumocytes do? |
|
Definition
replace Type 1 cells
produce surfactant proteins to prevent collapse & provide antimicrobial effects |
|
|
Term
| A lack of exposure to microbes early in life can lead to what? |
|
Definition
| atopic diseases such as asthma, severe allergies etc. due to antibody-mediated hypersensitivity reactions |
|
|
Term
|
Definition
| secrete antimicrobial peptides |
|
|
Term
| Where are Panth cells found? |
|
Definition
|
|
Term
| Where are Clara cells found> |
|
Definition
|
|
Term
True or False
The colon has more villi than the SI |
|
Definition
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|
Term
|
Definition
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