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Citric acid cycle
fate of pyruvate
14
Biochemistry
Undergraduate 1
05/13/2013

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Term
Acetaldehyde
Definition
acts as final electron acceptor in alcohol fermentation. reduced to ethanol
Term
Pyruvate
Definition
acts as final electron acceptor in lactic acid fermentation reduced to lactate
Term
Pyruvate dehydrogenase complex
Definition
oxidizes pyruvate to acetyl coA, located in mitochondria
Term
pyruvate dehydrogenase (Eι)
Definition
bound to cofactor thiamine pyrophosphate, TPP
Term
dihydrolipoyl transcetylase (E²)
Definition
bound to lipoyl group
Term
dihydrolipoyl dehydrogenase (E³)
Definition
with cofactor flavin adenine dinucleotide, FAD and NAD
Term
1: citrate synthase
Definition
oxaloacetate (4C) plus acetyl coA (2C) to give citrate (6C)
Term
2: aconitase
Definition
citrate is a poor substrate for oxygen. so additon of water by aconitase generates isocitrate.
Term
3: isocitrate dehydrogenase
Definition
good substrate for oxidation. produces one molecule of CO2 and one NADH
Term
4: α-ketoglutarate dehydrogenase complex
Definition
one molecule of CO2 and one molecule of NADH
Term
5: succinyl-CoA synthetase
Definition
pi displaces CoA to succinyl phosphate. phosphoryl group transferred to GDP
Term
6: succinate dehydrogenase
Definition
succinate dehydrogenated by this enzyme whose electron acceptor is FAD to form fumarate and FADH2
Term
7: fumarase
Definition
Hydration
Term
8: malate dehydrogenase
Definition
NAD+ acts as electron acceptor and 1 molecule of NADH produced
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