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Lecture 19
Lecture 19 material
6
Immunology
Undergraduate 4
05/08/2013
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Term
T cell development stages
 Definition

-DN1: CD44+Kit+CD25-

-DN2: CD44+Kit+CD25+

-DN3: CD44(low)Kit(low)CD25+, pTa:B

-DN4: CD44-CD25-, pTa:B proliferation

-large double positive: CD4+CD8+, pTa:B

-small double positive: CD4+CD8+, TCR (a:B)

-single positive: CD4+ or CD8+, TCR (a:B)
Term
anergy
 Definition
-TCR cross linking with weak affinity souble self-antigens
Term
transgenic mice
 Definition
-whole animals with extra copies or altered copies of a gene
Term
transgenic mouse procedure
 Definition

-microinject gene into male pronucleus of fertilized egg

-implant into pseudo-pregnant female

-mate for 10 generations to look for stability
Term
chimeric mice
 Definition
a single organism with each of two or more genetically distinct cell populations
Term
chimeric mouse process
 Definition

-irradiate mouse to kill all pluripotent stem cells

-harvest stem cells from another mouse

-inject into irradiated mouse
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