Term
|
Definition
-body surfaces lined by mucus secreting epithelium
-Gi tract
-upper and lower respiratory tract
-urogenital tract
-exocrine glands |
|
|
Term
|
Definition
-underlying layer of connective tissue
-not immune cells |
|
|
Term
|
Definition
-Gut Associated Lymphoid Tissue
-secondary lymphoid tissue
-peyer's patches
-mesenteric lymph nodes
-isolated lymphoid follicles
-palatine tonsils, adenoids, lingual tonsils |
|
|
Term
|
Definition
-antigen and/or pathogen presentation at mucosal surfaces
-unique content of lymphoid cells, hormones, immune modulators
-mesenteric lymph nodes, Peyes patches, develop independently of systemic immune system in fetus
-exposure to massive amounts of antigen, pathogens, food, microbiota |
|
|
Term
| mucosal immunity: systemic lymph nodes and spleen |
|
Definition
-antigen and/or pathogen presentation in skin, muscule, or bloodstream
-unique content of lymphoid cells, hormones, immune modulators
-systemic immune sustem differentiates independently of the mucosal immune system in the fetus |
|
|
Term
|
Definition
-located in the small intestine wall
-regions of lymphoid tissue
-site of immune response initiation in the gut
-100-200 in the small intestine of humans
-germinal centers present
-rich in B cells
-epithelial dome |
|
|
Term
|
Definition
-folded luminal surface
-do not secrete digestive enzymes or mucus
-directly exposed to organisms and particles
-route of entry into peyer's patches from lumen |
|
|
Term
| conventional epithelial cells |
|
Definition
-known as "enterocytes"
-secrete digestive enzymes, mucus
-microvilli on the luminal surface
-microvilli, mucus prevents direct exposure to organisms and particles
-prevent Peyer's patch entry |
|
|
Term
| sequence of events: peyer's patch |
|
Definition
-endocytosis/phatocytosis/transcytosis occurs
-folded M cell membrane forms a pocket
-dendritic cells and lymphocyts reside in the pocket
-antigen released into pocket
-dendritic cells take up transcytosed material
-antigen loaded dendritic cells migrate from dome region to T-cell area of peyer's patch
-neive t cells activated by dendritic cells
-primed T cells and dendritic cells activate B cells
-class switching occurs
-IgA secretion by transcytosis |
|
|
Term
| definition: oral tolerance |
|
Definition
-immune response suppression to a parenterally delivered antigen by first administering that antigen orally
-the immune system's ability to develop tolerance to orally digested antigens |
|
|
Term
|
Definition
-don't have virulence factors that damage tissue, therefore no inflammation
-don't have pattern recognition antigens. IgA made against commensals to keep them in check
-some commensals block transcription of inflammation mediators |
|
|
