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Lecture 14 Antigen-Receptor Diversity Part I
MHC Antigen-Receptor Diversity Part I
27
Immunology
Undergraduate 4
04/05/2015

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Cards

Term
Where are the genes encoding MHC Class I and II found?
Definition
in the MHC complex
Term
What are the 3 compartments of the MHC complex?
Definition
Class I Genes
Class II Genes
Class III Genes (NK-receptors, TNF alpha/beta genes etc)
Term
True or False

The MHC is found on the same chromosome across a wide variety of species
Definition
False

Found on different chromosomes
Term
True or False

Genes within the MHC complex are found in the same position across a wide variety of species
Definition
true
Term
What are the functional human MHC Class I Genes?
Definition
HLA-A, HLA-B and HLA-C
Term
What are the functional human MHC Class II genes?
Definition
DP, DQ and DR with alpha & beta chain versions for each

e.g. DRB = DR beta
Term
How is the porcine MHC complex different from humans? (3)
Definition
Class II and Class III genes are separated by the centromere on Ch7

pigis only have 3 functional Class Ia genes

pigs express Class II DR and DQ but not DP
Term
What Class II genes do pigs not express?
Definition
Class II DP
Term
How many class Ia genes do pigs have? How many are functional?
Definition
11

3 are functional
Term
HLA is to humans as ____ is to pigs
Definition
SLA
Term
How is the bovine MHC complex different from humans?
Definition
-have Class IIa and IIb regions on ch23 due to an inversion

-do not express Class II DP

-have unique genes DYA, DYB and DI

-DQA, DQB and DRB are highly polymorphic

-6 class Ia genes, only 3 are functional
Term
How many class Ia genes do cows have? How many are functional?
Definition
6

3 functional
Term
How many genes does the chicken MHC complex have?
Definition
19
Term
What chromosome is the bovine MHC complex found on?
Definition
23
Term
What chromosome is the porcine MHC complex found on?
Definition
7
Term
What chromosome is the chicken MHC complex found on?
Definition
16
Term
What are the two regions of the chicken MHC copmlex?
Definition
B & Y
Term
What genes are expressed in the chicken MHC complex?
Definition
DM

Class Ia
Term
Why are chickens potentially highly susceptible to viral infections?
Definition
they only have a single dominant Classs Ia gene which is highly polymorphic
Term
Describe the structure of the peptide-binding cleft of the MHC class Ia receptor
Definition
2 alpha helices and a B sheet
Term
What factors affect the binding affinity of the Class Ia receptor?
Definition
point mutations
reciprocal recombination
gene conversion
Term
The peptide binding cleft of a MHC Class II molecule is comprised of ...
Definition
alpha-1 and beta-1 domains of the alpha and beta chains
Term
True or False

It is possible that each human has a unique HLA haplotype
Definition
true
Term
Which individual would be more likely to be resistant to disease, one with DPa/DPb genes or DPa/DPa?
Definition
the heterozygote
Term
SLA alleles are associated with what disease?
Definition
Trichinella spiralis
Term
Chicken B21 is (resistant/susceptible) to Marek's disease
Definition
resistant
Term
Chicken B19 is (resistant/susceptible) to Marek's disease
Definition
susceptible
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