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Lecture 13
Lecture 13 material
9
Immunology
Undergraduate 4
05/06/2013

Additional Immunology Flashcards

 


 

Cards

Term
humoral immunity
Definition

-adaptive immunity (specific)

-B cells are main players

-extracellular spaces bathed in Ig's

-Ig production

-immunity can be transferred to another naive individual

Term
cell mediated immunity
Definition

-adaptive (specific)

-T cells are main players (CD8 and CD4)

-cannot be transferred to a naive recipient

Term
naive B cells meet antigen
Definition

-meet in secondary lymphoid tissue (lymph node or spleen)

-encounter complementary antigen

-activated by thymus dependent or thymus-independent methods

Term
conventional dendritic cells
Definition

-made in bone marrow (myeloid lineage)

-professional antigen presenting cell

-take up antigen in peripheral tissues by phagocytosis

-present antigen on MHC

-reside in tissues

-travel to peripheral secondary lymphoid organs via lymph vessels

Term
follicular dendritic cells
Definition

-origin unknown

-found in follicles of secondary lymphoid organs

-present antigen to B cells

Term
B cell immune response phase I
Definition

-primary lymphoid follicles

-no germinal center

-B cells proliferate

-prompt secretion of mostly IgM isotype

Term
B cell immune response phase II
Definition

-secondary lymphoid follicles contain germinal centers

-more effective B cell response

-somatic hypermutation

-class switching

Term
vaccine adjuvants
Definition

-water in oil

-oil in water

-aluminum hydoxide AlOH

Term
ELISA method
Definition

-coat microtiter plate with purified antigen. let sit for 30-60 minutes and wash away unbound with buffer. 

-cover with unrelated protein and wash again

-add serum to be tested for specific antibody and allow to bind. wash off unbound antibody

-add anti-Ig that binds to Fc portion. wash off unbound

-add chromogenic substrate. incubate to develop color

-measure color in spectrophotometer

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