Fluphenazine Decanoate

• Tmax: 8-24hrs
• Vehicle: Sesame oil
• EPS/TD risk: Higher
•  Starting Dose: 12.5-25mg
• Target dose: 12.5-50mg
• Max dose: 100mg/dose
• PO overlap: Recommended

Haloperidol Decanoate

• Tmax: 3-9 days
• Vehicle: Sesame oil
• EPD/TD risk: Higher
• Starting dose: 10-20x PO dose
• Target dose: 10-15x daily PO dose
• Max dose: 100mg 1st dose; 400mg/mo
• PO overlap: Recommended

Risperidone LAI

• Risperdal Consta
• Tmax: >3 weeks
• Vehicle: Microspheres in aqueous sol.
• EPD/TD: Lower
• Starting dose: 25mg + PO dose x 3 wks
• Target dose: 25-50mg
• Max dose: 50mg
• PO overlap: required

Paliperidone palmitate

• Invega Sustenna
• Tmax: 13 days
• Vehicle: Aqueous sol.
• EPD/TD risk: Lower
• Starting dose: 234mg then 156mg 8 days later
• Target dose: 117mg (39-234mg)
• Max dose: 234mg
• PO overlap: not required

Olanzapine Pamoate

• Zyprexa Relprevv
• Tmax: ~1 wk
• Vehicle: aqueous sol.
• EPD/TD risk: Lower
• Starting/Target dose: 150-300mg Q2w or 405mg Q4w
• Max dose: 300mg Q2w or 405mg Q4w
• PO overlap: Not required