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| a demoplastic tumor is supported by an extensive connective tissue (collagen is what robbin's mentions) system. Some cancers of the female breast are stony hard or "scirrhous" |
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| a benign epithelial neoplasm derived from the glands |
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| benign neoplastic growths that appear 'finger like' or 'warty' macro or microscopically |
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| adenomas that are cyst-like |
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| neoplasm, benign or malignant, produces a macroscopically visible projection above the mucosa |
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malignancies that arise in mesenchymal tissue
Gr. sar=fleshy
e.g. fibrosarcoma, chondrosarcoma, leiomyosarcoma, rhabdomyosarcoma. |
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| derived from any epidermis |
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| pleomorphic ade/sarc/carcinoma vs teratoma |
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| pleomorphic are usually multiple cell types of only one germ layer |
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| lack of differentiation. indicative of malignancies |
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| benign tumors look like what? |
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| the tissue tehy are derived from |
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| what are some defining characteristics of anaplasia? |
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-pleomorphism: size of cells differ -abnormal nuclear morphology -mitosis (not a strong indicator, however bizarre mitotic figures are indicative) -loss of polarity -ischemic necrosis |
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| replacement of one cell type with another |
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| disordered growth: loss of uniformity |
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| where do you find nearly all cervical squamous cell carcinomas/epithelial neoplasms? |
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| episomal vs integrated papilloma virus |
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episomal = dna not integrated into the genome integrated = derp
low grade lesions can be associated with either one of these |
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| low grade, productive HPV infection of the cervix are called...(2) |
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Definition
| flat condyloma & cervical intraepithelial neoplasia (CIN) I: collectively called 'low grade intraepithelial lesions. |
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| productive hpv on the vulva/perineum: |
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| condyloma acuminatum (papillary, cauliflower-like) |
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| squamous cell infected by HPV that undergoes a number of morphological changes: nuclear enlargement, nuclear hyperchromasia, perinuclear clear zone |
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| high grade productive HPV infection of the cervix are called... |
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| CIN II and III. these are moderate and severe dysplasia, respectfully. this is also known as carcinoma in situ. These are complete neoplastic transformations, and while they are not metastatic, they have a higher potential for transformation than low grade (CIN I) lesions. |
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| polyp without a stalk--vast majority of polyps |
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