Term
|
Definition
1. RF
2. ANA
3. ESR
4. CRP
5. Synovial fluid analysis |
|
|
Term
|
Definition
| antibody that is abnormally directed against the Fc region of IgG |
|
|
Term
| RF is commonly present in which two conditions? |
|
Definition
1. Sjogren's (100%)
2. RA (80%) |
|
|
Term
| presence of this Ab is 90-95% specific for RA |
|
Definition
|
|
Term
| the combination of positive results in these 2 labs gives a 99.5% specificity for the dx of RA: |
|
Definition
| +RF & +Anti-CCP = 99.5% specific |
|
|
Term
| useful in identifying inflammatory arthritis in patients with negative RFs |
|
Definition
| Anti-CCP (RF titer is low in early disease) |
|
|
Term
| group of antibodies directed against nucleic acid and nucleoproteins within the nucleus and cytoplasm: |
|
Definition
| ANA (anti-nuclear antibodies) |
|
|
Term
| 4 common immunofluorescent staining patters of ANA |
|
Definition
1. Speckled
2. Homogenous
3. Nucleolar
4. Nuclear rim |
|
|
Term
| which ANA staining pattern is most associated with SLE & RA? |
|
Definition
|
|
Term
| ANA staining pattern infrequently seen in patients with SLE |
|
Definition
|
|
Term
| ANA staining pattern that correlates with antibodies to double-stranded DNA predominantly seen in SLE |
|
Definition
|
|
Term
| important for the dx and classification of various forms of vasculitis: |
|
Definition
| Antineutrophil Cytoplasmic anitbodies (ANCA) |
|
|
Term
|
Definition
1. proteinease3
2. myeloperoxidase (MPO)
both are granules of neutrophils and lysomes of monocytes |
|
|
Term
| immunofluorescence skin test: when to use? whats it for? |
|
Definition
| use when +ANA, -anti-dsDNA & -anti-Smith for the dx of SLE |
|
|
Term
| associated with spondyloarthropathies: |
|
Definition
|
|
Term
|
Definition
1. ankylosing spondylitis
2. Juvenile ank spon
3. Psoriatic Arthropathy
4. Sacroiliitis
5. intestinal arthropathies (UC/Chrones)
6. Reactive arthropathy (reiter's syndr) |
|
|
Term
| to detect deficient tear production in sjogren syndrome |
|
Definition
| Schirmer's Test - fluoroscene eye drops, graduated filter paper |
|
|
Term
| Schirmer's test result for pt with sjogren's syndrome |
|
Definition
| <5mm on graduated filter paper |
|
|
Term
| 4 dz assoc w keratoconjunctivitis sicca |
|
Definition
1. sjogren
2. SLE
3. RA
4. systemic sclerosis |
|
|
Term
| ESR is primarily determined by the ____ level in inflammation |
|
Definition
|
|
Term
| may be norml in early inflammatory condition |
|
Definition
|
|
Term
| normal range of ESR increases with 2 conditions |
|
Definition
|
|
Term
| which is more sensative ESR or CRP |
|
Definition
| CRP both more sensitive and specific |
|
|
Term
| serum and urine samples often used to R/o osteoarthritis and pseudogout |
|
Definition
|
|
Term
|
Definition
| present in the SKmm, liver and brain, it is a marker used for inflammatory myopathy w/o elevation of CPK |
|
|
Term
| this test has false positives in the presence of autoantibodies |
|
Definition
|
|
