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Lab Animal Science 2
Rodent Diseases, Rodent Breeding, Rabbits, Guinea Pigs, Hamsters and Gerbils
191
Agriculture
Undergraduate 2
04/25/2008

Additional Agriculture Flashcards

 


 

Cards

Term
Alopecia
Definition
Hair Loss
Term
Barbering
Definition
Behavioral hair chewing.  As long as the skin appears normal, the mouse does not require treatment.
Term
Ulcerative Dermatitis
Definition
Very pruritic (itchy) skin lesions in C57B16 mice.
Term
Flakey Skin Disease
Definition
Sometimes seen in nude mice, caused by a skin infection with Corynebacterium bovic, a gram-positive bacterium.
Term
Treatment of Flakey Skin Disease
Definition
Antibiotics in drinking water.
Term
Characteristic wound locations on fleeing mice.
Definition
Tails, rear feet, genitals.
Term
Treatment if fight wounds is severe.
Definition
Euthanasia.
Term
Hydrocephalus
(definition)
Definition
A swelling of malformation of the brain and overlying skull (usually the forehead region).  This condition cannot be treated, and results in rapid decline and death.
Term

Ribs, vertebrae, pelvic bones, and all bony promineces evident when feeling animal though it's fur.

(Too thin, Ideal, or Too Heavy?)

Definition
Too thin.
Term

Ribs are palpable through a covering of fat, but cannot feel the spine.  The coat is thick and glossy.

(Too thin, Ideal, or Too Heavy?)

Definition
Ideal
Term

Massive fat deposits over the thorax, spin and base of tail.

(Too thin, Ideal, or Too Heavy?)

Definition
Too Heavy
Term

Dystocia

(definition)

Definition
Trouble delivering pups in a normal manner.
Term

Anasarca

(Definition)

Definition
Generlized edema or swelling.
Term
ARC upper limit on MICE tumor size.
Definition
1.5cm
Term
ARC upper limit on RAT tumor size.
Definition
2.5cm
Term
Two ways a male can have Penile Prolapse?
Definition

1:  Very active breeding.

2:  Fighting.

Term
This is sometimes associated with an ear infection.
Definition
Head Tilt
Term
What will a mouse with Head Tilt do when picked up by the tail?
Definition
Spin
Term

Porphyrin

Definition
Choromodacryorrhea - a red substance secreted by the Harderian gland, located behind the eye.
Term

Proptosis

(definition)

Definition
Distension or protrusion of the globe of the eye.
Term

Degloving

(definition)

Definition
Loss of flesh from around the bone of a rodent tail that may be caused by picking up the rat too close to the tip of it's tail.
Term
# of adult mice <25g that may be housed per standard cage.
Definition
5
Term
max # of mice >25g housed together in a standard cage?
Definition
4
Term
Max # Adults that may be housed with a litter in a standard cage?
Definition
2
Term
# days to remove sutures.
Definition
14 days.
Term
Rat estrous cycle duration
Definition
4-5 days
Term
4 stages of mice estrous cycle.
Definition

Proestrus

Estrus

Metestrus

Diestrus

Term
Light Cycle
Definition
Critical for normal estrous cycling.
Term
Puberty of male mice.
Definition
5-6 weeks.
Term
Puberty of female mice.
Definition
4-5 weeks
Term
# of weeks to begin breeding female mice?
Definition
6 weeks
Term
How long for male mouse to be housed along prior to breeding?
Definition
1 week.
Term
Three pheromone effects.
Definition

1. Lee-Boot Effect

2. Whitten Effect

3. Bruce Effect

Term
Lee-Boot Effect
Definition
Estrus suppression (anestrus) in females housed together for about 2 weeks.
Term
Whitten Effect
Definition
Induction of estrus in females by the presence of the mail or male's urine.
Term
Bruce Effect
Definition
Phermones from a strange male may prevent implantation of the embryon in recently (4-5 days) bred females.
Term
When does mice ovalation occur?
Definition
4-5 hours after the start of the dark cycle.
Term
What indication is there that a mating has occured?
Definition
A copulatory plug.
Term
Mice gestation period.
Definition
19-21 days.
Term
Days before a mouse can be visually pregnant.
Definition
12-13 days
Term
How many days after pregnancy should a female mouse be left alone?
Definition
17 days.
Term
Time birth usually occurs for a mouse.
Definition
12-4am.
Term
Mouse litter size.
Definition
1-12 pups.
Term
Postpartum Estrus of a mouse.
Definition
12-28 hours.
Term
# days a newborn mouse opens eyes.
Definition
12-14 days.
Term
hen do mice pups start to eat solid foods?
Definition
Day 11 or when eyes open.
Term
How long do female mice lactate?
Definition
Around 4 weeks.
Term
Mice external ears open after how long?
Definition
3 days.
Term

Rabbit

(Scientific Name)

Definition
Oryctolagus corniculus
Term
Most common rabbit breed used in biomedical research.
Definition
albino New Zealand (white)
Term
Other common rabbit breeds (besides NZ)
Definition

Butch Belted

Flemish Giant

Polish

Chinchilla

 

Term

Male Rabbit - ?

Female Rabbit - ?

Baby Rabbit - ?

Definition

Male Rabbit - Buck

Female Rabbit - Doe

Baby Rabbit - Kit

Term
Distinguishing Characteristics of Rabbits
Definition
  • High muscle/bone ration with large body fat reserves.
  • Female larger than males
  • Limbs are long - hindlimbs are longer
  • No foot pads. Long-straight claws.
  • Small rudamentry clavical
  • Thick and soft fur except for the nose and scrotum
  • Secondary set of incisors - hypodontic - Peg or Wolf Teeth.
Term
What order is the Rabbit?
Definition
Lagomorpha
Term

Rabbit Research Uses

Definition
  • Disease models
  • Serum/Antibody Production
  • Drug Screening
  • Pyrogen Testing
  • Atherosclerosis Testing
Term

Body part of rabbit that is never used for restraining.

Definition

Ears

Term
Rabbit Temperature
Definition
100.4 - 104.0
Term
Rabbit heart rate
Definition
130-325 bpm
Term
Rabbit Respiration Rate
Definition
30-60
Term
Rabbit p02
Definition
85-102
Term
Rabbit Blood Pressure
Definition

Systolic: 90-130

Diastolic: 80-90

Term

Rabbit Weight

Adult?

New Born?

Definition

Adult: 2-6kg

Newborn: 30-80g

Term

Rabbit Water Consumption

Definition
100-600m/day
Term
Rabbit Food Consumption
Definition
100-300g/day
Term
Rabbit Lifespan
Definition
5-8 years
Term
Rabbit Urine
Definition
Clear->yellow->red brown
Term

Rabbit pH

Definition
Alkaline - 8.2
Term
Rabbit Urine Volume
Definition
50-75 ml/kg/day
Term
Rabbit Coprophagy
Definition
Rabbits produce a night stool which is a softer pellet covered in mucus which they ingest to regain vit B and protein.  Fecal production 50-60g/day
Term
Rabbit Hypnosis
Definition
Cradle on his back tipping the head backwards until he's "out."
Term
Shedding Rabbits
Definition
Rabbits shed every 3 months.
Term
Rabbit litter.
Definition
kindling
Term
Sign of rabbit about to give birth.
Definition
Pulling out her own fur from the chest, abdomen, throat to line box.
Term
Rabbit Sexual Maturity
Definition
4-6 months.
Term
Rabbit ovulators.
Definition
Induced Ovulators
Term
Rabbit Breeding.
Definition
Female must be taken to male cage.  Female will attack male in her own cage.
Term
Rabbit Gestation
Definition
29-35 days
Term
Rabbit litter size.
Definition
4-10 kits
Term
Rabbit Cannibalism?
Definition
YES
Term
Rabbit Weaning
Definition
4-6 weeks.
Term
Rabbit Behavior
Definition
  • Females fight unless raised together.
  • Active and Curious
  • Adept at escaping from unsecured cages
  • Generally mild tempered
  • Sesitive to noice
  • Naturally Nocturnal
  • Most active at twilight
  • Easily Excitable
  • Occasionally resist handling
Term
Rabbit Sniffing
Definition
Annoyed or just talking.
Term
Rabbit Grunts
Definition
Angry
Term
Rabbit Shrill Scream
Definition
Hurt/Dying/Terrified
Term
Rabbit circling feet.
Definition
Sexual behavior - In Love.
Term
Rabbit Spraying
Definition
Territorial Marking.
Term
Rabbit Chinning
Definition
Territorial Marking
Term
Rabbit Hopping/Dancing
Definition
Pure Joy and happiness
Term
Rabbit Begging
Definition
for treats
Term
Rabbit Territorial Droppings.
Definition
Marking
Term
Rabbit Playing
Definition
Pushing and tossing objects.
Term
Rabbit Stomping
Definition
Mad - Warning
Term
Rabbit Teeth Grinding
Definition
Shows contentment
Term
Rabbit Room Temp
Definition
61-71
Term
Rabbit Humidity
Definition
30-70%
Term
Rabbit Flea Treatment.
Definition
  • Frontline is never to be used.
  • Flea powders are not recommended.
  • Flea Shampoos are not recommended.
Term
Rabbit Coccidiosis
Definition

Poor Sanitation.

Diarrhea, fever, anorexia, weight loss, emaciation, dearh.

Dx: fecal flotation, intestinal lesions

Tx: Sulfonamides and good husbandary.

Term
Rabbit Pasteurellosis
Definition

Pasteureila Multocida

Multiple large, creamy filled abcesses occuring on the neck and mammary glands.  Sneezing, rhinitis, serous-mucopurulent, discharge from the nose.

Usually best to euthanize.

Term
Rabbit "Wry Neck"/Ear Infection
Definition

Middle/inner each infection.  Pus/fluid buildup, rabbit twists head.

Tx: long term antibiotic.  Prognosis is guarfded.  Easier to euthanize.

Term

Rabbit

Pododermatitis/"Bumblefoot"

Definition

Staphylococcus Aureus

Round ulcerated lesions on the plantar surfaces of the foot.  Very painful.

Analgesia.  Clean surface. antibiotics.

Term

Rabbit

Treponematosis/Spirochetosis/Syphillis

Definition

Not zoonotic.

Small cesicles or ulcers formed covered with heavy scabs in genital region, lips, and eyes.

Benzathring Peniccilan - Infected for life.

Term

Rabbit

Tyzzer's Disease

Definition

Found in all species of lab animals throughout the world.

Profuse diarrhea, anorexia, lethary, death (1-3 days in rabbits 6-12 weeks old), necrotic enteritis with necrosis in liver and heart.

Tetrocyclin added to water.

Term

Rabbit

Myxomatosis

Definition

Used to attempted eradication of rabbits in Australia.

Insect vectors and direct contact.

High mortality rate.  Conjunctivitis, pyrexia, anorexia, lethargy.  death within 2 days.

No treatment.

Term

Rabbit

Rotavirus type A

Definition

Transmission - fecal-oral route

Severe watery diarrhea, anorexia, dehydration.  Mortality rate 80%+ for < 6 months old.

Leads to secondary infections -> e.coli/clostridium

No treatments.

Term

Guinea Pigs

Scientific Name

Definition
Cavia procellus
Term

Guinea Pigs

Originated

Definition
Andes mountains of South America
Term

Guinea Pigs

relations

Definition
Chinchilla and Porcupine
Term

Guinea Pigs

Most Common Breed

Definition
Duncan-Hartley (albino)
Term

Guinea Pigs

Research purposes

Definition
  • Nutrition
  • Immune System Function
  • Infectious Disease Studies (tuberculosis)
Term

Guinea Pigs

Behaviour

Definition

Docile

Can't climb or Jump

Wide Variety

Vocal

Fastidious eating habits, messy

Long gestation length

Dependence on Vit C

Herbivores

Excellent Swimmers

Male-Dominated

Term

Guinea Pigs

Anatomical Characteristics

Definition
  • tailless
  • Short/Stocky/compact
  • Short legs
  • M&F have nipples
  • Lower molars can commonly become maloccluded and overgrown.
Term

Guinea Pigs

Handling

Definition
One hand around chest with palm of the other placed under the hidwuarters whien lifting.
Term

Guinea Pigs

Body Temperature

Definition
98.6-103.1
Term

Guinea Pigs

Heart Rate

Definition
230-320
Term

Guinea Pigs

Respiratory Rate

Definition
42-104
Term

Guinea Pigs

Weight: Adult and Newborns

Definition

Adult: 500-800g

Newborns:  70-90g

Term

Guinea Pigs

Water Consumption

Definition
50-80ml/day
Term

Guinea Pigs

Food Consumption

Definition
30-48g/day
Term

Guinea Pigs

Feces

Definition

Firm dark pellet.

Copraphagic (150-200x/day)

Cecal Fermentors

Term

Guinea Pigs

Urine

Definition
Yellow and slightly cloudy.  Contains crystals
Term

Guinea Pigs

Lifespan

Definition
4-6 years.  8 years MAX.
Term

Guinea Pigs

Sexing

Definition
Male's penis felt under the skin in the inguinal area.
Term

Guinea Pigs

Breeding Weight

Definition

550-600g

(12 weeks)

Term

Guinea Pigs

7 month old females

Definition
Females older than 7 months are prone to Dystocia due to fusion of the pubic bone.
Term

Guinea Pigs

Estrous Cycle

Definition

6-11 hours long

16-18 days.

Term

Guinea Pigs

Gestation

Definition

60-64 days

Longest of rodents

Term

Guinea Pigs

Litter size

Definition
2-4
Term

Guinea Pigs

Male/Female

Definition

Male=Boar

Female=Sow

Term

Guinea Pigs

Cannibalism

Definition
RARE
Term

Guinea Pigs

Weaning

Definition
18-24 days
Term

Guinea Pigs

Precocious Young

Definition

Large, born fully furred, eyes open, able to eat solid food, able to run.

Term

Guinea Pigs

Sexual Maturity

Definition
60-90 days.
Term

Guinea Pigs

Diet

Definition
Diet must include Vit C since they do not make their own.  Prone to scurvy.
Term

Hamsters

Species

Definition

Chinese Hamster (Cricetulus griseus)

Syrian/Golden Hamster (Mesocricetus auretus)

Term

Hamsters

Research Use

Definition
  • Diabetes
  • Cancer
  • Transplant Studies
  • Genetics Studies
  • Dental/Cavity research.
Term

Hamsters

Cheek Pouch

Definition

Thin epithelial sac that extends into the check.

Used to store bedidng, food, and young.

Does not have any lymph.

Term

Hamsters

Stomach

Definition

2 compartments;

Non-glandular forestomach

Forestomach

Term

Hamsters

Scent Glands/Flank Organ

Definition

Located on R/L dorsolateral flanks.

Used as a sexual Attractant

Secretes a thick, musk-like fluid

 

Term

Hamsters

Handling

Definition
Scruffed or cupped in hands.
Term

Hamsters

Sexing

Definition

Male has testes and pointed posterior. 

Female is curved.

Term

Hamsters

Hand Mating

Definition

Female to male cage at the end of light cycle.  Separate after 5 minutes.

Term

Hamsters

Harem Mating

Definition

1M + 2-3F housed together.

Remove female 2-3 days before giving birth.

Term

Hamsters

Intermittent Mating

Definition
1 female paired with 1-2 males per week.
Term

Hamsters

Monogamous Mating

Definition

Pair is placed after being weaned. 

Litters should appear 35-40 days.

Term

Hamsters

Mating Systems

Definition

Hand Mating

Harem Mating

Intermittent Mating

Monogamous Mating

Term

Hamsters

Sexual Maturity

Definition
42-70 days
Term

Hamsters

Estrous Cycle

Definition
4 days
Term

Hamsters

Gestation

Definition

15-16 days

(shortest of species)

Term

Hamsters

Litter Size

Definition
5-10 pups
Term

Hamsters

Cannibalism

Definition
YES
Term

Hamsters

Weaning

Definition

21 days

(same as mice and rats)

Term

Hamsters

Behaviour

Definition
  • Nocturnal
  • Burrowers
  • Fastidious - Urinate/Defacate in separate area from food.
  • Escape Artists
  • Aggresive
  • Startle Reflex - Stand on hind legs and BITE.
  • Dominant Females
  • Immunologic tolerance
  • Deep Sleepers
  • Run on wheels 8km/day
Term

Hamsters

PseudoHibernate

Definition
When room temp is under 5c.
Term

Hamsters

Body Temp

Definition
98.6-100.4
Term

Hamsters

Heart Rate

Definition
250-600
Term

Hamsters

Resp Rate

Definition
35-120
Term

Hamsters

Weight

Adult and Newborn

Definition

Adult: 80-120g

Newborn: 8-12g

Term

Hamsters

Water Consumption

Definition
10ml/100g/day
Term

Hamsters

Food Consumption

Definition
10ml/100g/day
Term

Hamsters

Feces

Definition
Firm, rice sized, dark brown
Term

Hamsters

Urine

Definition
Thick and milky
Term

Hamsters

Lifespan

Definition
1.5 - 2 years.
Term

Gerbils

Scientific Name

Definition

Mongolian Gerbil

Meriones unguiculatus

Term

Gerbils

Known for...

Definition
  • Ease of handling
  • Friendly and curious
  • Mild temperment
  • Adaptive to environmental changes
  • Low occurance of natural disease
  • Active and naturally orderless and clean.
  • Most resistant to radiation exposures
Term

Gerbils

Research uses

Definition

Stroke

Epilepsie or spontaneous siezures

Term

Gerbils

Seizures

Definition
20% epleptic seizures, caused by stress, handling, loud noises.  Appears to freeze, tiwtch, and kick.  Begins at 2 months old.  Seizures range from mild to severe.
Term

Gerbils

Handling

Definition
Grab at base of tail or cup in hands
Term

Gerbils

Breeding Behaviour

Definition
Monogamous for LIFE!
Term

Gerbils

Sexual Maturity

Definition
80-84 Days
Term

Gerbils

Estrous Cycle

Definition
4-6 Days
Term

Gerbils

Gestation

Definition
24-26 days
Term

Gerbils

Litter Size

Definition
4-5
Term

Gerbils

Cannibalism

Definition
NO
Term

Gerbils

Weaning

Definition

21 days

Eat solids at 16-20 days

Term

Gerbils

Sexing Methods

Definition

Anogenital distance

Males is twice as long as females. 

Males have a darm scrotum.

Term

Gerbils

Manic

Definition
High level of activity, then crashes.
Term

Gerbils

Diurnal

Definition
Active in the daytime.
Term

Gerbils

Activities

Definition
  • Build nests
  • Constantly digging, borrowing, elaborate tunnels
  • Interacting, socialization
  • Constantly grooming themselves and others
  • Scratch at side of cages.
Term

Gerbils

Ventral Marking Glands

Definition

Yellow gland in both sexes.

Used for sexual attraction, marking territory, and marking pups.

Term

Gerbils

Body Temp

Definition
96.3-102.7
Term

Gerbils

Heart Rate

Definition
260-600
Term

Gerbils

Resp Rate

Definition
70-120
Term

Gerbils

Weight

Adult and Newborn

Definition

Adult: 70-90g

(m: 80-90g - f: 70-80g)

Newborn: 3g

Term

Gerbils

Water Consumption

Definition
3-6ml/day
Term

Gerbils

Food Consumption

Definition

4-7g/day

equal amounts day and night

Term

Gerbils

Feces/Urine

Definition
Similar to mouse
Term

Gerbils

Life Span

Definition
2-4 Years
Term

Gerbils

Foot Stomping

Definition

Indicates a threat nearby

or

Sexual attraction or ritual

Term

Gerbils

Escape Behaviour

Definition

Explorer/curious

tend to stay close to cage areas

may even return to their cage

Term

Gerbils

Diet

Definition

Same rodent chow as rats and mice.

Water is ad lib.

Term

Gerbils

Zoonotic Concerns

Definition

Salmonella

Hymenolepsis infections.

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