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L6 Substance Exposure
Creighton University School of Medicine
38
Medical
Post-Graduate
02/27/2013

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Cards

Term
Term
Definition
Definition
Term
Newborn exposure to illegal drugs
Definition
1/10 newborns
Term
Immaturity of the lungs
Definition
respiratory distress syndrome
Term
Meconium aspiration
Definition
Meconium enters lungs in utero, causes severe respiratory problems
Term
Leading cause of mental retardation worldwide
Definition
Heavy alcohol consumption
Term
Common symptoms of FAS
Definition
Hyperactivity, short attention span, language dysfunction, delayed maturation
Term
Alcohol Damage to Fetus
Definition
Directly toxic, impairs supply of nutrients and oxygen, derangges protein synthesis, fetal malformations by disrupting normal hormone levels
Term
Alcohol effects during pregnancy/delivery
Definition
Increase OB complications, spontaneous abortion/miscarriage/stillbirth (related to dose)
Term
Alcohol effects on newborn
Definition
Low weight, IUGR, more damaging if drinking during last trimester
Term
IUGR increases the risk for
Definition
Early death, respiratory difficulties, feeding problems, serious infection, long-term dev problems. Withdrawal/tremors/hypertonia/sleeping problems/reflex abnormalities/poor sucking
Term
Leading cause of low birth weight and IUGR
Definition
tobacco is the leading cause
Term
FAS Incidence
Definition
5,000 born annually, 1-3 births/1,000, mental abnormality in 85% of FAS kids
Term
FAS diagnosis based on
Definition
Mothers alcohol use, growth deficiency (pre and/or postnatal weight below 10%), CNS abnormalities, dysmorphic features
Term
FAS CNS abnormality dianosis
Definition
Head circumference < 10%, brain abnormalities on MRI, neurologic problems, global cognitive/intellectual deficits
Term
FAS dysmorphic features diagnosis
Definition
All 3 must be present: short palpebral fissures, indistinc philtrum(++), thin upper lips
Term
Alcohol and breastfeeding
Definition
Alcohol transmitted through breast milk, heavy drinking decreases milk supply/ejection
Term
Tobacco effects on newborn
Definition
Subtle behavior abnormalities, mild withdrawal, higher risk of dying before first birthday
Term
Tobacco effects on breastfeeding
Definition
Nicotine transmitted, inhibit milk production and vit. C in milk
Term
Tobacco effects on growing child
Definition
Impaired growth, behavior problems, poorer congitive skills, increased sickness/SCID
Term
Cocaine effects on the fetus
Definition
constricts blood vessels, heart variability, CNS/intestinal/Uro/limb abnormalities
Term
Cocaine effects on pregnancy/delivery
Definition
higher abortion/placental abruption, early labor, used to induce abortions, outcomes improve if stopped during last trimester but vessel damage is irreversible
Term
Cocaine effects on newborn
Definition
Higher risk for IUGR/SIDS, withdrawal, jittery, shrill cry, easily startled, poor feeding, abnormal sleep, tremors, increased muscle tone,
Term
Cocaine effects on breastfeeding
Definition
May cause tremulousness, irritability, startle responses, seizures
Term
Cocaine effects on growing child
Definition
Not enough data but likely behavior problems, small changes in IQ/language ability
Term
Marijuana effects on pregnancy/delivery
Definition
Possible spontaneous abortion/stillbirths, easily crosses placenta
Term
Marijuana effects on newborn
Definition
Increased tremulousness, altered visual response patterns to light, short-term behavior problems, usually effects subside in 30 days
Term
Marijuana effects on breastfeeding
Definition
Trasmitted in breast milk, remains in milk for long periods
Term
Marijuana effects on growing child
Definition
Limited studies, possible delayed-maturationand diminished cognitive abilities
Term
Opiate use in pregnancy
Definition
Low birth weigh from IUGR or prematurity
Term
Opiates and neonatal abstinence syndrome
Definition
In 60-80% of heroin-exposed infants, onset w/in 70 hours, causes CNS problems like: irritability, abnormal sucking, seizures,diarhhea,vomiting,tachypnea,sneezing,yawning,sweating
Term
Opiate use in pregnancy delayed effects
Definition
Subacute withdrawal, associated with SIDS, delayed growth, neurologic performance, cognitive development, decreased attention span
Term
Methamphetamine vs. Cocaine
Definition
similar effects, concaine half-life 1-2 hours, meth half-life 8-12 hours
Term
Meth effects on pregnancy
Definition
Poor prenatal care, poor nutrition (IUGR), placental abruption, asphyxia, premature
Term
Meth effects on infant (animal studies)
Definition
Exencephaly, ribs abnormal, cleft palate, microgyria, cerebral ectopy, hemorrhage and meningeal abnormalities, anophthalmia, behavior effects
Term
Hawaii birth defects program
Definition
includes all infants/fetuses delivered in Hawaii
Term
Finigin Score purpose
Definition
An objective assessment of an infants withdrawal symptoms
Term
Finigin Score - scoring
Definition
Scoring every 4 hours at 2 hours of age, score of 5 = withdrawal, ≥8 three consecutive times = treatment
Term
Meconium drug testing
Definition
This test produces high rates of false negatives
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