Term
| Identify the major plasma lipoproteins and the tissue(s) in which each is formed |
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Definition
Chylomicron- intestines
VLDL- liver
LDL- formed in circulation from IDL
HDL- formed in liver and small intestines |
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Term
| Identify the major lipid(s) and apolipoproteins associated with each lipoprotein |
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Definition
hylomicron- TAG, B-48 (A,C,E)
VLDL- TAG, B-100
IDL- TAG and Cholesterol, B-100, E
LDL- Cholesterol, B-100
HDL- Cholesterol, A's (C,E) |
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Term
| Predict the consequences of an excess of chylomicrons or VLDL on serum TAGs. |
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Definition
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Term
| Predict whether the concentration of chylomicrons is a better indicator of consumption of dietary carbohydrates or dietary fats. Do the same for VLDL. |
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Definition
chylomicrons- indicator of dietary fat consumption (transports dietary TAG)
VLDL- indicator of dietary carbohydrates (transports endogenously made TAG) |
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Term
| Identify the apoprotein component, common to both VLDL and chylomicrons, that is responsible for activating lipoprotein lipase |
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Definition
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Term
| Identify the apoprotein component, common to chylomicrons, VLDL, and IDL that is involved with clearing the chylomicron remnants and IDL after most TAGs have been hydrolyzed |
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Definition
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Term
| Identify the apoprotein of LDL that binds to the LDL receptor |
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Definition
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Term
| Explain the proposed mechanism of action for drugs that are used to lower serum cholesterol levels |
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Definition
-inhibit HMG- CoA reductase, enzyme used to synthesize cholesterol
- increase the production of LDL receptors to increase uptake of circulating LDL from blood |
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Term
| Explain the role of LDL receptors and clathrin coated pits in removal of LFL |
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Definition
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Term
| Predict the consequences of a defect in functional LDL receptors on cholesterol biosynthesis, formation of intracellular cholesterol esters, and serum, cholesterol levels |
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Definition
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Term
| Explain how HDL's are involved with "reverse cholesterol transport" |
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Definition
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