Term
| The Krebs cycle is involved in the breakdown of what metabolic fuels? |
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Definition
| Carbohydrates, Fats (and Ketone bodies), Proteins |
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Term
| Where in the cell does the Krebs Cycle occur? |
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Definition
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Term
| How much energy does the Krebs Cycle produce? What is the breakdown? |
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Definition
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Term
| What is the first step of the Krebs Cycle? |
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Definition
Oxaloacetate -> Citrate (tricarboxylic acid)
via Citrate Synthase |
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Term
| What inhibits the enzyme Citrate synthase? |
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Definition
ATP
Acetyl-CoA
NADH
Citrate
Succinyl CoA |
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Term
| What is the second step of the Krebs Cycle? |
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Definition
Citrate -> Isocitrate
via: aconitase |
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Term
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Definition
| Fluoroacetate (rat poison, turns into fluoroacetyl CoA) |
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Term
| What is the third step of the Krebs cycles? |
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Definition
Isocitrate -> alpha-ketoglutarate
via Isocitrate dehydrogenase |
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Term
| What inhibits Isocitrate dehydrogenase? |
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Definition
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Term
| What upregulates isocitrate dehydrogenase? |
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Definition
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Term
| What is a downstream metabolic consequence of inhibiting isocitrate dehydrogenase? |
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Definition
| Will cause a buildup of Citrate. Citrate inhibits PFK-1 in glycolysis and also stimulates Fatty Acid synthesis |
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Term
| What is the fourth step of the Krebs Cycle? |
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Definition
alpha-ketoglutarate -> Succinyl coa
via alpha-ketoglutarate dehydrogenase |
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Term
| What inhibits alpha-ketoglutarate dehydrogenase? |
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Definition
| ATP, NADH + H+, and Succinyl CoA |
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Term
| What upregulates alpha-ketoglutarate? |
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Definition
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Term
| What is the fifth step of the Krebs Cycle? |
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Definition
Succinyl CoA -> Succinate
Succinyl CoA Synthetase |
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Term
| Besides the Krebs cycle, when else is alpha-ketoglutarate produced? |
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Definition
| In the transamination of glutarate |
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Term
| what upregulates Succinyl CoA synthetase? |
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Definition
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Term
| In what other metabolic pathways is Succinyl CoA produced? |
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Definition
| In the metabolism of fatty acids and amino acids |
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Term
| What is the sixth step of the Krebs Cycle? |
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Definition
Succinate -> Fumarate
via Succinate dehydrogenase |
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Term
| What is the seventh step of the Krebs Cycle? |
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Definition
Fumurate -> Malate
via Fumarase |
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Term
| What is the 8th Step of the Krebs Cycle? |
|
Definition
Malate -> Oxaloacetate
via Malate dehydrogenase |
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