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Kinetics equations
Kinetics
9
Other
Not Applicable
05/15/2013
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Term

Digoxin 

  • Loading dose equation
 Definition

Dose = (Conc*VD)

                 F

(1)
Term

Digoxin

  • Maintanance dose equation
 Definition

Dose = Cl*conc*t

                F

t = 24h

(10)
Term

IBW

  • Male
  • Female
 Definition
  • 50kg + 2.3/inch above 5'
  • 45.5 + 2.3/inch above 5'
Term
Adjusted BW
 Definition
Adjusted = IBW + 0.4(Actual-Ideal)
Term
Calculate T>mic
 Definition

Kel = ln (Cmax/Cmin)

             T

t = time>mic

(2)
Term
VD (using Cmid)
 Definition

VD =      Dose     

       (Cmid-Cmin)
Term
BSA
 Definition

               

      lcm*kg

    \l 3600
Term

Phenytoin 

  • Clearance equation
 Definition

Cl =  Vmax

      Km + C
Term

Phenytoin

  • Corrected Conc
 Definition

Cactual =    Cobserved

             (0.2*alb) +0.1
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