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| mathematical study of the time-drug concentration relationships of absorption, distribution, biotransformation, and excretion of drugs, toxins, exogenous and some endogenous substances |
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| mathematical study of drug concentration at the site of action as related to the magnitude of effect |
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| first dose - amount remaining |
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| knew avg fatal dose of digitalis, reinfused animals until cardiac event, found difference between fatal and second dose equals amount remaining |
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| administered digitalis until symptoms appeared, discontinued, re-dosed until toxicity reappeared. found average amount lost per day was amount in second dose divided by number of days |
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| Is the volume of fluid that the drug WOULD occupy IF it was evenly distributed through that volume at the concentration measured in the SERUM |
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| fraction of drug presented to the eliminating organ which is cleared after a single pass |
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| assumptions: unbound fraction remains the same both inside and outside the organ, and intrinsic clearance = rate of elimination/unbound concentration |
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| If fu x intrinsic clearance is greater than flow (limited by flow) |
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| if drug elimination is limited by intrinsic ability of organ to clear drug and the fu |
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| tend to be more impacted by drug interactions |
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| fraction lost during interval (accumulation factor) |
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| fraction of peak remaining at t time after dose |
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