Term
| What is normal Creatine level? |
|
Definition
|
|
Term
| What is Pharmacodynamics? |
|
Definition
|
|
Term
| What is Pharmacokinetics? |
|
Definition
| How the drug moves in the body |
|
|
Term
| Differences between Prescribed, OTC, and dietary supplements |
|
Definition
OTC-FDA approved
Dietary-FDA warned |
|
|
Term
|
Definition
|
|
Term
|
Definition
| medicine getting into the blood |
|
|
Term
| How does food effect bioavailability? |
|
Definition
| decreases effect of absorption |
|
|
Term
| Critical point with extended release drug formulations |
|
Definition
| DO NOT CRUSH--- affects delivery system---toxicity can occur |
|
|
Term
| Local drug administration examples |
|
Definition
| inhalers, ointments, nasal sprays, eyedrops |
|
|
Term
| Which route of administration is more likely to cause side effects? |
|
Definition
|
|
Term
| What are the 4 factors affecting absorption? |
|
Definition
| Food, Blood flow and health status, stomach pH and other drugs |
|
|
Term
| What are systemic formulation examples? |
|
Definition
|
|
Term
|
Definition
| How drug moves in the body; is "distributed" in body tissues |
|
|
Term
| Ionization and bioavailability |
|
Definition
Like absorbs like
acidic-stomach
alkaline-small intestine |
|
|
Term
| What are patient factors that contribute to low albumin (value <3.o |
|
Definition
| liver dysfunction, malnutrition |
|
|
Term
| What is the difference between a bound drug and a free drug? |
|
Definition
a bound drug is bound to the protein, a free drug is in the plasma.
more free drug can lead to toxicity. |
|
|
Term
|
Definition
| allows drug to change to get out of the body |
|
|
Term
| What are some CYP450 inducers and what do they do? |
|
Definition
Grapefruit, Nicotine..
speed up the metabolism by increasing enzymes |
|
|
Term
| What are some CYP450 inhibitors and what do they do? |
|
Definition
Tagamet, Alcohol
decrease metabolism by decreasing enzymes |
|
|
Term
| What is the first pass effect? |
|
Definition
| PO, how much of a drug is left after being metabolized in the liver. |
|
|
Term
|
Definition
Drug leaving the body
(sweat, poop, urine, breath) |
|
|
Term
| What does it mean when your creatine is high? |
|
Definition
| Clearance is low; renal dysfxn |
|
|
Term
|
Definition
| time it takes for drug to decrease by 1/2 |
|
|
Term
|
Definition
half life times 4.
.. amount of drug removed via elimination equal amount of durg absorbed. |
|
|
Term
| What is a loading dose and why do we give it? |
|
Definition
| a larger than maintenance dose is given in order to reach a therapeutic level quicker. |
|
|
Term
|
Definition
| how the drug works--- interaction between cell and drug |
|
|
Term
|
Definition
| the results; therapeutic response |
|
|
Term
| What is a therapeutic response? |
|
Definition
| the desired or intended response |
|
|
Term
| What is an Adverse response? |
|
Definition
| unpredictable, undesired effect of drug |
|
|
Term
|
Definition
| strength of attraction between drug and binding site. |
|
|
Term
|
Definition
| stimulator; works with drug |
|
|
Term
|
Definition
| Inhibitor; works against drug or blocks effect |
|
|
Term
| What are signs/symptoms of hypokalemia? |
|
Definition
| N/V, tremors, weakness, constipation |
|
|
Term
| What are s&s of hyPERkalemia? |
|
Definition
| N/V, muscle spasms, cardiac dysrhytmias, diarrhea |
|
|
