# Shared Flashcard Set

## Details

Kinetic formulas
fundamentals
12
Pharmacology
08/31/2010

Term
 Rate of elimination
Definition
 -  -KeC (the elimination rate) -the rate of elimination is proportional to the concentration of the drug -1st order kinetics
Term
 Time course of drug concentration
Definition
 -C(t)=C0-ket C0= concentration at time 0
Term
 half life
Definition
 t1/2=.693/Ke
Term
 Volume of Distribution
Definition
 -Relates the concentration of drug in the compartment(plasma) to the amount introduced -Vd=dose/C0 -if you know the Vdthen you can predict what the concentration change of the drug in the plasma will be after a bolus injection of the drug -normalized to body weight l/kg **not an actual volume, it is the volume needed to account for all drug introduced into the system at a given plasma concentration
Term
 Clearance
Definition
 -relates the rate of elimination to plasma concentration     Elimination rate=CL*C unitls of ml/min/kg CL-->amount per drug per unit time Ke-->change in concentration per unit time (mg/ml)/hour
Term
 Clearance related to half life
Definition
 t1/2=.693Vd/CL
Term
 Non-instaneous Delivery official definition of Vd
Definition
 -We can still get the elimination rate constant from the late decay phase, but we can't extrapoalate to t=0 to get C0 and thus Vd -so we use the official definition of Vd -Vd=dose/(keAUC)
Term
 Constant Infusion (Css)
Definition
 -The delivery rate must equal the elimination rate -Dosing rate-CL*Css -generally takes 4-5 half lives to reach steady state
Term
 central compartment
Definition
 -plasma-liver-kidney -if drug is added instantaneously to central compartment, it will take some time before it is evenly distrubuted throughout the body -this is the distribution phase and the drug concentration will fall more rapidly than during the later elimination phase
Term
 Multiple Dose regimen
Definition
 -each bolus of drug raises the plasma concentration (ΔC) by -ΔC=dose/Vd
Term
 Phase I reaction
Definition
 -convert drug to more polar metabolite (thus increasing its water solubility -add a polar functional group (-OH, -NH2. -SH -always change the pharmacologic activity of the drug
Term
 Phase II
Definition
 -polar substances or polar functional groups acquired during phase I are conjugated to endogenous polar substrates such as glucuronic acid, sulfuric acid, acetic acid, or glycine -almost all conjugated products are completely inactive
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