Term
| Which congenital kidney problem results in oligohydraminos? |
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Definition
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Term
| Which congenital kidney problem can cause urinary tract obstruction? |
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Definition
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Term
| Which disorder has no visible basement membrane changes, fused epithelial foot processes, lipid accumulation in rental tubular cells? |
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Definition
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Term
| What are the morphologic findings of focal segmental glomerulonephritis? Nephritic or nephrotic? |
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Definition
| no visible basement membrane changes, segmental sclerosis of scattered juxtamedullary glomeruli, nephrotic |
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Term
| Name the nephrotic disorder - basement membrane markedly thickened by intramembranous and epimembranous (subepithelial) immune complex deposits, granular immunofluorescence, spike and dome appearance. Nephritic or nephrotic? |
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Definition
| membranous glomerulonephritis, nephrotic |
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Term
| What are the morphological findings of diabetic nephropathy? |
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Definition
| Basement membrane markedly thickened, diffuse or nodular mesangial accumulations of basement membrane-like material |
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Term
| Name the disorder - protein deposits identified by Congo red staining, birefringence under polarized light, or electron microscopic criss-cross fibrillary pattern. Nephritic or nephrotic? |
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Definition
| renal amyloidosis, nephrotic |
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Term
| What are the morphologic findings of lupus nephrosis? Nephritic or nephrotic? |
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Definition
| immune complex deposition in subendothelial location, may manifest as membranous glomerulonephritis, nephrotic but some cases may present with nephritic symptoms |
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Term
| Which nephritic disorder has subepithelial electron-dense humps, or "lumpy-bumpy" immunofluorescence? |
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Definition
| post-strep glomerulonephritis |
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Term
| Name the disorder - crescents, ANCA-negative forms with immune complexes or antiglomerular basement membrane antibodies, ANCA-positive (pauci-immune) form with Wegener granulomatosis |
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Definition
| Rapidly progressive (crescentic) glomerulonephritis |
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Term
| What are the morphological characteristics of Goodpasture syndrome? |
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Definition
| Linear immunofluorescence caused by anti-GBM antibodies |
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Term
| Which disorder has the morphological characteristic of a split basement membrane? |
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Definition
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Term
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Definition
| IgA nephropathy, with mesangial IgA deposits |
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Term
| Which disorder has the morphological characteristic of a tram-track appearance, deposits of C3 and dense deposits (in one variant) |
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Definition
| membranoproliferative glomerulonephritis |
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Term
| Membranous glomerulonephritis should be suspected when nephrotic syndrome is accompanied by... |
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Definition
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Term
| This disorder is seen in 10% of pts with SLE, is associated with some types of infectious disease, and can cause renal vein thrombosis |
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Definition
| membranous glomerulonephritis |
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Term
| What are Kimmelstiel-Wilson nodules, and which disorder are they associated with? |
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Definition
| nodular accumulations of mesangial matrix material, diabetic nephropathy |
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Term
| Which disorder is associated with an increase in mesangial matrix, with both diffuse and nodular glomerulosclerosis? |
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Definition
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Term
| Renal amyloidosis is associated with which other conditions? |
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Definition
| chronic inflammatory disease like rheumatoid arthritis and plasma cell disorders like multiple myeloma |
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Term
| What are the types of lupus nephropathy? |
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Definition
| Type 1 - no renal involvement, Type 2 - mesangial form, Type 3 - focal proliferative form, Type 4 - diffuse proliferative form, Type 5 - membranous form |
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Term
| Which disorder is associated with a wire-loop abnormality? |
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Definition
| Type 4 lupus nephrosis, from immune complex deposition and gross thickening of the GBM |
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Term
| What are the major clinical findings of nephritic syndrome? |
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Definition
| Oliguria, azotemia, hypertension, hematuria |
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Term
| What type of disease is post-strep glomerulonephritis? What is the antigen? |
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Definition
| immune complex disease, the antigen is of streptococcal origin |
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Term
| Name the disorder - intense inflammatory reaction, innumerable punctuate hemorrhages on kidney surfaces, enlarged hypercellular swollen bloodless glomeruli, GBM of normal thickness and uniformity, subepithelial electron-dense humps, lumpy bumpy immunofluorescence |
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Definition
| post-strep glomerulonephritis |
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Term
| Where are the crescents in RPGN? How do they happen? |
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Definition
| Crescents are between the Bowman capsule and glomerular tuft, from deposition of fibrin and proliferation of parietal epithelial cells |
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Term
| What are some of the immune complex forms of RPGN? |
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Definition
| Post-strep (50%), SLE, IgA |
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Term
| RPGN with non-streptococcal anti-GMB antibodies are seen in 10% of cases, these often present clinically as... |
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Definition
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Term
| What is the pauci-immune type of RPGN (type III)? |
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Definition
| No immune complex deposition (as in Type II) or anti-GBM antibodies (as in Type I), associated with ANCA |
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Term
| Name the disorder: nephritic syndrome, hemorrhagic pneumonitis, men in mid-20d, RPGN crescents, linear immunofluorescence |
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Definition
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Term
| How does focal glomerulonephritis differ from FSGN? |
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Definition
| it is focal and segmental, but changes are inflammatory and proliferative rather than sclerotic. Most often it is an immune complex disease, occurring with SLE, SBE, PAN, Goodpasture, Wegener, IgA, can also be idiopathic |
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Term
| Which syndrome is a hereditary nephritis associated with nerve deafness and ocular disorders like lens dislocations and cataracts? |
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Definition
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Term
| What causes Alport syndrome? |
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Definition
| mutation in gene for alpha-5 chain of Type IV collagen |
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Term
| Which disorder is most often characterized by benign recurrent hematuria in children, usually following an infection, lasting 1-2 days, and most often of minimal significant? |
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Definition
| IgA nephropathy (Berger disease) |
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Term
| Berger disease can also be a component of which other disease? |
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Definition
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Term
| Name the disorder - characterized clinically by slow progression to CRD, histologically by both basement membrane thickening and cellular proliferation, duplication of GBM into two layers with a tram-track appearance on silver stains? |
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Definition
| Membranoproliferative glomerulonephritis |
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Term
| What is Type I membranoproliferative glomerulonephritis? |
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Definition
| immune complex nephritis, unknown antigen, striking tram-track appearance |
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Term
| What is Type II membranoproliferative glomerulonephritis? |
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Definition
| characterized by irregular electron-dense material deposited within the GBM, C3 is demonstrable and adjacent to but not within the dense deposits, serum C3 characteristically reduced. Possibly caused by IgG autoantibody (C3 nephritic factor) with specificity for C3 convertase of the alternate pathway |
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