Term
| are Ca+ channel blockers helpful in heart failure? |
|
Definition
| no - they cause too much cardiac depression |
|
|
Term
| what common effect of digoxin can be blocked by atropine? |
|
Definition
| increased PR interval on the EKG |
|
|
Term
| DOC for severe acute heart failure w/marked pulmonary edema? |
|
Definition
|
|
Term
| what drug will prolong life in CHF pts as well as have negative effect on cardiac contractility? |
|
Definition
|
|
Term
| what beta 1 agonist is sometimes used in acute heart failure? |
|
Definition
|
|
Term
| should hyperkalemia be avoided with procainamide usage? |
|
Definition
| yes, hyperkalemia facilitates procainamide toxicity |
|
|
Term
| what is an ADR for loop diuretics? |
|
Definition
|
|
Term
| where does spironolactone work? |
|
Definition
|
|
Term
| where does furosemide work? how much Na secretion can it incur? |
|
Definition
|
|
Term
| where do thiazides work? what Na load? |
|
Definition
| DCT - 5-10% of the Na load |
|
|
Term
| would HCTZ increase serum K+? |
|
Definition
|
|
Term
| why would drugs that interfere with aldosterone (ACE inhibitors, AT-1 blockers) be contraindicated in hyperkalemia? |
|
Definition
| these block aldoesterone which stimulates the Na/K pump to kick out K and keep Na (and thus water) |
|
|
Term
| can mannitol help in cerebral edema? |
|
Definition
|
|
Term
| is orthostatic hypotension associated with furosemide? |
|
Definition
|
|
Term
| can acetazolamide cause comas in pts with cirrhosis? |
|
Definition
| yes, acetazolimide can cause metabolic acidosis and urinary alkalosis. urinary alkalosis causes urea (which the liver can no longer process) to become ammonia gas, which is rapidly reabsorbed = hyperammonia = coma |
|
|
Term
| what drugs can dilute urine (in water loaded subjects) and are used to treat SIADH (ectopic ADH secretion)? |
|
Definition
| conivaptan and democycline - which block the V2 receptor in the collecting duct from ADH stopping diuresis |
|
|
Term
| can niacin help raise HDL? |
|
Definition
|
|
Term
| can bile acid binding resins raise VLDL in pts with familial hyperlipidemia? |
|
Definition
|
|
Term
|
Definition
|
|
Term
| what form of lipid does alcohol ingestion raise? |
|
Definition
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