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JAK-STAT pathways
EXAM 2
21
Medical
Professional
09/07/2010

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Term
when JAK activates STAT, what happens to STAT?
Definition
it is released when phosphorylated, they bind together, enter the cell, and begin transcription.
Term
What does SOCS3 inhibit?
Definition
it blocks JAK activation of STAT
Term
what does CIS inhibit?
Definition
inhibits STAT activation
Term
what is the action of SOCS1?
Definition
bind to JAK and prevent activation
Term
what are receptor serine kinase ligands?
Definition
homodimeric peptide ligands held together by cysteine disulfide bonds
Term
How is TGF beta signaling occuring?
Definition
receptor serine kinases
Term
what does TGF beta signaling activate?
Definition
members of the SMAD family
Term
how is the SMAD protein activated?
Definition
type 2 activates type 1, which then phosphorylates the SMAD protein
Term
what binds in conjunction with SMAD to activate transcription in the nucleus
Definition
co-SMAD, and cofactor
Term
what activates SMAD 2 and 3?
Definition
TGFbeta/Activin/Nodal signaling
Term
what activates SMAD 1, 5, and 8
Definition
BMP signaling
Term
what do all SMAD ligands require?
Definition
R-Smad interaction with the Common mediator Smad 4
Term
R-Smads are the only to contain this
Definition
ssxs phosphorylation motif
Term
what are the anti SMADs
Definition
6 and 7
Term
what is the function of MH1 and 2?
Definition
1-DNA binding
2-protein-protein interactions
Term
middle white linker is the site of what
Definition
MAPK/ERK phosphorylation
Term
what is the function of the BAMBI
Definition
binding to type 2 receptor, preventing activation of R-SMAD
Term
binding of hedgehog does what?
Definition
inhibits patched, leading to activation of Smoothened and subsequent activation of Gli/Ci
Term
what does wnt binding do?
Definition
leads to stabilization of Beta catenin and downstream signaling.
Term
what is the action of TNF (IL-1) on NFkB
Definition
activation
Term
explain delta notch signaling
Definition
it directs cell-cell interaction during development.

proteolytic cleavage of the notch goes into the nucleus and activates transcription.
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