angitis

arteritis

T/F

vascultits can only be from infections?

False

it can also be from immunologic reactions

-soluble antigen-antibody complexes

-complexes deposit on arterial wall

-complexes activate complement

-PMNs attach

-release lysosomal enzymes

-damage and necrosis

Giant cell arteritis (temporal)

Takayasu arteritis

polyarteritis nodosa

Kawasaki disease (Mucocutaneous Lymph Node Syndrome)

thromboangitis obliterans

(Buerger's)

Wegener's granulomatosis

Allergic granulomatosis (Churg Strauss Syndrome)

Leukocytoclasic vasculitis (hypersensitivity)/Microscopic polyangitis

What are the characteristics of Allergic granulomatosis angitis

(Churg-Strauss Syndrome)?

-systemic vasculitis  with lots of eosinophilia

-ppl with asthma

-necrosis od small and medium arteries, arterioles, veins

-intra and extra vascular granulomas

What is hypersensitivity angiitis

(leukocytoclastic)?

-affects small vessel

-all lesions occur around the same time

-fibroid necrosis and fragmented neutrophils in walls

-necrosis, granulomatous inflammation, vasculitis of small arteries and veins

-necrotic granulomas of upper and lower respiratory tract

-renal disease

-sinusitis, pneumonitis, hematuria, proteinuria

What does this describe?

-focal, chronic granulomatous inflammation of large and medium muscular vessels

-affects temporal and cranial arteries

-gives visual problems in half of patients

-affects aortic arch

-mononuclear infiltrate of adventitia (gets thick)

-affects young women

-pulseless disease

-affects kids

-thrombosis

-fever, rash, conjunctival/oral lesions

-necrosis vasculitis

-coronary artery aneuryms

-occluded and inflammed small/medium vessels

-extremities

-vascular wall polys

thrombosis with microabscess

intermittent claudication and severe pain

-young women get vasoconstriction of vessels in extremities from a cold or emotional stimuli

-benign course

-no underlying disease

-atherosclerosis

-cystic medial necrosis

-rupture with massive hemorrhage

-impingement on adjacent structures

-occlusion of vessels

-emboli

arteriosclerotic

syphilitic

dissecting

-age

-being a woman

-pregnancy

-genes

-obesity

hemorrhoids

esophageal varices

thrombophlebitis

phlebothrombosis

What is

thrombophlebitis?

What is

phlebothrombosis?

-cardiac failure

-neoplasia

-pregnancy

-postop state

-prolonged bed rest

-radial surgery

-filariasis

-postradiation fibrosis

-potinflammatory thrombosis and scarring

-malignant tumors

-benign

-intermediate (borderline/ low-grade malignant)

-malignant

-capillary hemangioma

-cavernouse hemangioma

-pyogenic granuloma

-glomus tumor (glomangioma)

-telangiectasis(vascular ectasias)

-lymphangiomas

-largest single group

-juvenille strawberry typre capillary hemangiomas

-in large vascular channels

-can be in the brain

-bleed easily and often ulcerate

-don't reoccur after excision

-most seen on fingers/ toes/ under nails

-painful to touch

-group of abnormal blood vessels

-focal red lesion

-congenital

- in the lymph

-can be cavenous

-in children in the neck

-dilated disk spaces/ not encapsulated

-hemangioendothelialioma

-Kaposi Sarcoma

-primarily endothelial cells

-in skin, spleen, liver

-epithelioid hemangioendothelioma are around medium and large veins

-chronic (classic/European)

-lymphadenopathis (African/Endemic)

-transplant-assciated

-AiDS-associated (Epidemic)

-in older men

-multiple red/purple nodules in lower extremities

-localized to the skin and subcutaneous tissue

-in transplant recipients with high dose immunosuppressice therapy

-localized to skin or widely metastatic

-in AIDS patients

-mostly homosexual men

-in various areas but involved in lymph nodes and gut early

-angiosarcomas

-hemangiopericytoma

-malignant neoplasms with masses of endothelial cells

-in elderly

-most often seen on skin, breast, soft tissue, and liver

-rare

-come from pericytes

-common in extremities

-highyl malignant

-metastasize to lungs, bone, liver