Term
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Definition
| Carries heme iron across the BBM into the cytosol. Found in proximal SI |
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Term
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Definition
| involved in iron transport. Contains integrin, mobilferrin, monooxygenase flavin. Reduces Fe3+ to Fe2+ |
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Term
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Definition
| duodenal cytochrome b --> reductase on BBM that turns Fe3+ into Fe2+ so that it can go into the enterocyte |
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Term
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Definition
| divalent cation/mineral transporter 1. Found on BBM, brings Fe2+ into the cell |
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Term
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Definition
| brings Fe3+ into the enterocyte |
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Term
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Definition
| endogenous chelator in gastric and mucosal cells. Binds Fe3+ in acid pH and maintains solubility in alkaline environment |
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Definition
| natural resistance associated macrophage protein 2 - divalent apical membrane iron transporter |
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Term
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Definition
| interacts with integrin at the BBM. Shuttles ferric iron around the cell. |
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Term
| Ferroportin (Fp)/MTP1/Ireg1 |
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Definition
| membrane spanning protein transporter across the BLM - Fe2+ exporter. Trnasport coupled to oxidation so Fe2+ --> Fe3+ |
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Term
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Definition
| multi copper oxidase (ceruloplasmin homologue) that oxidizes Fe2+ to Fe3+, so it can bind to transferrin for transport. |
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Term
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Definition
| main transport protein in blood. Can carry up to 2 Fe's |
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Term
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Definition
| ferroxidase that converts Fe2+ --> e3+ for transport in transferrin |
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Term
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Definition
| stimulator of Fe transport. Pumps Fe out of the endosome. |
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Term
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Definition
| degraded or aggregated ferritin |
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Term
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Definition
| storage form of Fe in cells. Can store up to 4500 Fe molecules. Not stable, so constantly broken down and remade |
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Term
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Definition
| binds hemoglobin in iron turnover |
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Term
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Definition
| binds free heme in iron turnover |
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Term
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Definition
| portein on the BLM involved in iron uptake, efflux and absorption. Takes iron into enterocyte from the blood. Acts as iron sensor. Not function in HH. |
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Term
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Definition
| inhibits iron transport by binding to ferroportin. This promotes iron storage. |
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