Term
|
Definition
| Lowering plasma cholesterol levels in all types of hyperlipidemias. |
|
|
Term
|
Definition
They are the drugs of choice (in
combination with low-fat diet or
niacin) in treating type IIA and IIB
hyperlipidemias. |
|
|
Term
|
Definition
They are the drugs of choice (in
combination with low-fat diet or
niacin) in treating type IIA and IIB
hyperlipidemias. |
|
|
Term
|
Definition
For the treatment of
hypertriglyceridemia (type IV and V).
• Useful in patients with mixed
hyperlipidemia (type IIB).
• To increase HDL cholesterol levels in
patients with HDL deficiency |
|
|
Term
|
Definition
For the treatment of hypertriglyceridemia (type IV and V).
• Useful in patients with mixed
hyperlipidemia (type IIB).
• To increase HDL cholesterol levels in
patients with HDL deficiency |
|
|
Term
|
Definition
Most effective single drug in the
treatment of mixed hyperlipidemia
(type IIB) and hyperlipoproteinemia
(type IV), in which both VLDL and
LDL are elevated.
It is the most potent antihyperlipidemic agent for raising
plasma HDL levels. |
|
|
Term
|
Definition
Useful in the treatment of Type IIA and
IIB hypercholesterolemia. It’s usefulness is limited to instances in which other antihyperlipidemic agents
are ineffective. |
|
|
Term
|
Definition
| Long-term management of patients with deep venous thromboembolism (VTE) or atrial fibrillation or artificial heart valve |
|
|
Term
|
Definition
Preoperative prophylaxis against deep vein thrombosis (VTE).
Administered following MI or
pulmonary embolism (PE).
Heparin prevents clotting in arterial and heart surgery, during blood transfusion, and in renal
dialysis and blood sample collection (in vitro
effect).
Used for initiation of anticoagulation therapy.
Can be used in pregnancy. |
|
|
Term
| Low-molecular-weight heparins |
|
Definition
| Inhibit factor IIa and factor Xa |
|
|
Term
|
Definition
Recombinant DNA-derived polypeptide.
in the treatment of deep vein
thrombosis (DVT) and heparin-induced
thrombocytopenia (HIT). |
|
|
Term
|
Definition
synthetic molecule that reversibly binds to thrombin.
in the treatment of heparininduced
thrombocytopenia (HIT). |
|
|
Term
|
Definition
| Decrease thromboxane A2 production in platelets |
|
|
Term
|
Definition
| It inhibits adenosine diphosphate (ADP)-induced expression of platelet glycoprotein receptors and reduces fibrinogen binding to platelets. |
|
|
Term
|
Definition
It is Fab fragment of a chimeric human-murine monoclonal antibody.
It is used solely for the prevention of
thrombosis in patients undergoing coronary
angioplasty.
It binds to platelet glycoprotein IIb/IIIa receptors (GP IIb/IIIa) and prevents binding by fibrinogen, and consequently, aggregation
does not occur.
• Eptifibatide and tirofiban, act similarly to abciximab by blocking the GP IIb/IIIa receptor. |
|
|
Term
|
Definition
Fibrinolytic Drug
Recombinant forms of human tissue plasminogen activator (t-PA) |
|
|
Term
|
Definition
Fibrinolytic Drug
Protein obtained from human urine |
|
|
Term
|
Definition
Fibrinolytic drug
A protein obtained from streptococci |
|
|
Term
|
Definition
Fibrinolytic drug
complex of streptokinase and plasminogen |
|
|
Term
|
Definition
H1 Blocker (1st gen)
Allergic Conditions, Motion Sickness
Vertigo, Sedation, NOT the drug of choice for acute anaphylaxis |
|
|
Term
|
Definition
H1 Blocker (1st gen)
Allergic Conditions, Motion Sickness
Vertigo, Sedation, NOT the drug of choice for acute anaphylaxis |
|
|
Term
|
Definition
H1 Blocker (1st gen)
Allergic Conditions, Motion Sickness
Vertigo, Sedation, NOT the drug of choice for acute anaphylaxis |
|
|
Term
|
Definition
H1 Blocker (2nd gen)
Allergic Conditions, Motion Sickness
Vertigo, Sedation, NOT the drug of choice for acute anaphylaxis |
|
|
Term
|
Definition
H1 Blocker (2nd gen)
Allergic Conditions, Motion Sickness
Vertigo, Sedation, NOT the drug of choice for acute anaphylaxis |
|
|
Term
|
Definition
H1 Blocker (2nd gen)
Allergic Conditions, Motion Sickness
Vertigo, Sedation, NOT the drug of choice for acute anaphylaxis |
|
|
Term
|
Definition
H1 Blocker (2nd gen)
Allergic Conditions, Motion Sickness
Vertigo, Sedation, NOT the drug of choice for acute anaphylaxis |
|
|
Term
|
Definition
|
|
Term
|
Definition
H2 Blocker
Inhibits gastric acid production. Promote healing of gastric and duodenal
ulcers. Treat GERD and for
prophylaxis of stress ulcers
Used for Hives |
|
|
Term
|
Definition
H2 Blocker
Inhibits gastric acid production. Promote healing of gastric and duodenal
ulcers. Treat GERD and for
prophylaxis of stress ulcers |
|
|
Term
|
Definition
H2 Blocker
Inhibits gastric acid production. Promote healing of gastric and duodenal
ulcers. Treat GERD and for
prophylaxis of stress ulcers |
|
|
Term
|
Definition
H2 Blocker
Inhibits gastric acid production. Promote healing of gastric and duodenal
ulcers. Treat GERD and for
prophylaxis of stress ulcers |
|
|
Term
|
Definition
5 HT1 agonist
Acute migraine NOT for prophylaxis |
|
|
Term
|
Definition
5 HT2 antagonist
Prophylactic migraine and vascular headaches. GI effects of carnicoid tumors |
|
|
Term
|
Definition
|
|
Term
|
Definition
5 HT3 antagonist
Can be used for schizophrenia, alcoholism and opioid addiction |
|
|
Term
|
Definition
5 HT4 agonist
Nausea and GI dysmotility
Class used for GERD and IBS |
|
|
Term
|
Definition
5 HT4 agonist
Nausea and GI dysmotility
Class used for GERD and IBS |
|
|
Term
|
Definition
Induce abortion in the second
trimester
Postpartum hemostasis |
|
|
Term
|
Definition
|
|
Term
|
Definition
Nsaid induced gastric ulcer
abortifacient w/ RU486 or methotrexate |
|
|
Term
|
Definition
Cervical ripening (gel)
Midtrimester abortion (supp) |
|
|
Term
|
Definition
Leukotriene receptor antagonist
asthma |
|
|
Term
|
Definition
5-lipoxygenase inhibitors
Asthma |
|
|
Term
|
Definition
Cox-1/Cox-2 inhibitor
Anti-inflammatory, Analgesic, anti-pyretic
Preventin of colon cancer
Bartters syndrome
Promote closure of the ductus
arteriosis
Antiplatelet |
|
|
Term
|
Definition
Cox-1/Cox-2 inhibitor
Anti-inflammatory, Analgesic, anti-pyretic
Preventin of colon cancer
Bartters syndrome
Promote closure of the ductus
arteriosis |
|
|
Term
|
Definition
Cox-1/Cox-2 inhibitor
Anti-inflammatory, Analgesic, anti-pyretic
Preventin of colon cancer
Bartters syndrome
Promote closure of the ductus
arteriosis |
|
|
Term
|
Definition
Cox-1/Cox-2 inhibitor
Anti-inflammatory, Analgesic, anti-pyretic
Preventin of colon cancer
Bartters syndrome
Promote closure of the ductus
arteriosis |
|
|
Term
|
Definition
Cox-2 selective inhibitor
Cox-1/Cox-2 inhibitor
Anti-inflammatory, Analgesic, anti-pyretic
Preventin of colon cancer
Bartters syndrome
Promote closure of the ductus
arteriosis |
|
|
Term
|
Definition
Cox-3 inhibitory
Analgesic, anti-pyretic |
|
|
Term
|
Definition
anti-inflammatory glucocorticoid
block induction of COX-2 at the transcription level |
|
|
Term
|
Definition
| Can be used as an adjunct to reduce nausea in patients with widespread cancer by reducing inflammation |
|
|
Term
|
Definition
Treatment of gout
Blocks transport of organic acids across the renal tubule, resulting in increased excretion |
|
|
Term
|
Definition
Anti-mitotic. Binds to tubulin.
Treatment of gout by preventing the migration of granulocytes (and other inflammatory cells) into inflamed area |
|
|
Term
|
Definition
Treatment of Gout
Inhibits Xanthine oxidase, which converts xanthine to uric acid |
|
|
Term
|
Definition
Treatment of rheumatoid arthritis
First line DMARD. Folic acid antagonist. Decrease inflammatory cells in the synovium. Reduces RA symptoms and slows joint damage |
|
|
Term
|
Definition
Treatment of RA
Anti-malarial drug that shows efficacy as a DMARD. Mechanism not clear |
|
|
Term
|
Definition
Treatment of RA
Reduces symptoms and joint damage but less effective than methotrexate. used in triple therapy |
|
|
Term
|
Definition
Treatment of RA
Efficacy cimilar to methotrexate, but MOA not entirle elucidated. |
|
|
Term
|
Definition
TNF inhibitor, Treatment of RA
Recombinant protein that binds to circulating TNF |
|
|
Term
|
Definition
TNF inhibitor, Treatment of RA
monoclonal antibody that binds TNF |
|
|
Term
|
Definition
TNF inhibitor, Treatment of RA
monoclonal antibody against TNF. "humanized" |
|
|
Term
|
Definition
| These have minimal anti-inflammatory effects in other situations, but cause reductions in the inflammation associated with RA |
|
|
Term
|
Definition
Treatment of RA
T-cell costimulatory blocker that interferes with interactions between antigen-presenting cells and T lymphocytes by binding to CD28. |
|
|
Term
|
Definition
Treatment of RA
Causes B cell depletion. Monoclonal antibody that binds to CD20 on B cells. |
|
|
Term
|
Definition
Treatment of RA
Recombinant IL-1 receptor antagonist. |
|
|
Term
|
Definition
Treatment of RA
Purine analog that inhibits purine synthesis. Anti-mitotic |
|
|
Term
|
Definition
Treatment of RA
Immune suppressant drug in transplant recipients. |
|
|
Term
|
Definition
Treatment of SLE
An alkylating agent that is also used in cancer chemotherapy. |
|
|
Term
|
Definition
PPI
Promote healing of gastric and duodenal ulcers and treat GERD that is unresponsive to H2 antagonist |
|
|
Term
|
Definition
PPI
Promote healing of gastric and duodenal ulcers and treat GERD that is unresponsive to H2 antagonist |
|
|
Term
|
Definition
PPI
Promote healing of gastric and duodenal ulcers and treat GERD that is unresponsive to H2 antagonist |
|
|
Term
|
Definition
PPI
Promote healing of gastric and duodenal ulcers and treat GERD that is unresponsive to H2 antagonist |
|
|
Term
|
Definition
| Creates a sticky gel that adheres to epithelial cells in a protective manner. Treats duodenal ulcers and for prophylaxis of stress ulcers |
|
|
Term
|
Definition
| Synthetic PGE1 analog, inhibits adenylate cyclase. Prevents NSAID-induced mucosal injury. |
|
|
Term
|
Definition
| Cleaved in the colon by bacterial enzymes to mesalamine (5-ASA) and sulfapyradine. 5-ASA inhibits both cox and 5-lipoxygenase pathways to treat ulcerative collitis, but NOT for Crohn's disease. |
|
|
Term
|
Definition
Calcium channel activator
PGE1 analog, but directly acts on ClC-2 chloride channels. Considered a laxative product, increases fluid secretion in the SI by activating Cl channels. |
|
|
Term
|
Definition
| Active moeity of sulfasalazine, avoiding the side effects of sulfapyridine. |
|
|
Term
|
Definition
| 5-HT3 antagonist. Therapeutic effect in IBS |
|
|
Term
|
Definition
5-HT4 partial agonist
Prokinetic agent for therapy of IBS with constipation, particularly in women. Withdrawn due to suggesting increased cardiovascular risk. |
|
|
Term
|
Definition
| inhibit GI motility via opioid receptors on nerve and muscle. Does not cross the BBB and effective against travelers diarrhea |
|
|
Term
|
Definition
| a bulk-forming laxative, is used to treat constipation |
|
|
Term
|
Definition
| Used in transdermal patches to reduce motion sickness and post-operative nausea. Not useful for chemotherapy-induced nausea |
|
|
Term
|
Definition
| Cannabinoid. used for prophylaxis of chemotherapy-induced emesis. Stimulates appetite as well. |
|
|
Term
|
Definition
| Can reduce the anticipatory component of nausea and vomiting, but are not really anti-emetics. |
|
|
Term
|
Definition
| anion-exchange resin that binds bile acids and some bacterial toxins. Used to treat bile salt-induced diarhea after ileal resection, |
|
|
Term
|
Definition
| A mineral. Has a mild antibiotic activity and appears to have anti-inflammatory effects. Can be used for diarrhea and mechanism is unclear. |
|
|
Term
|
Definition
| An immunoglobin which binds to and neutralizes TNF alpha. Approved to for use in moderate to severe crohn's disease (promotes healing) |
|
|
Term
|
Definition
| thought to act via physical means (osmotic, wetting agents) but can also stimulate secretion and contraction to help with constipation |
|
|
Term
|
Definition
| Introduces a solution into the lower bowel with the goal of evacuating its contents. Treat moderate to severe constipation |
|
|
Term
|
Definition
| Short acting B2 selective adrenergic agonist. Bronchodilation |
|
|
Term
|
Definition
| Long acting B2 selective adrenergic agonist. Bronchodilation |
|
|
Term
|
Definition
| Methylxanthine related to caffeine. Inhibits PDE, which helps with relxation of bronchi and inhibits mast cell degranulation (due to increased cAMP). anti-inflammatory effects due to Adenosine receptor antagonist. Reduce inflammation in COPD |
|
|
Term
|
Definition
| Blocks Muscarinic receptors in bronchial smooth muscles. Alternative to B2 agonists . Slower onset of action. |
|
|
Term
|
Definition
| Inhibits antigen-induced drganulation of mast cells. Suppresses many inflammatory cells. Inhibits irritant nerves. Prophylactic; most effective in allergen-induced asthma. |
|
|
Term
|
Definition
| Oral Glucocorticoid. Antiinflammatory and inhibits production of inflammatory cytokines. First-line treatment in moderate to severe asthma |
|
|
Term
|
Definition
| Inhaled Glucocorticoid. Antiinflammatory and inhibits production of inflammatory cytokines. First-line treatment in moderate to severe asthma |
|
|
Term
|
Definition
| Inhaled Glucocorticoid. Antiinflammatory and inhibits production of inflammatory cytokines. First-line treatment in moderate to severe asthma |
|
|
Term
|
Definition
| LTD4-receptor antagonist. Effective against antigen-induced asthma, EIA, and mild asthma, but not strongly anti-inflammatory. |
|
|
Term
|
Definition
5-lipoxygenase inhibitor
Blocks production of leukotrienes |
|
|
Term
|
Definition
| Recombinant monoclonal antibody aginst IgE. Effective in moderate asthma, but expensive |
|
|
Term
|
Definition
| Splits disulfide bonds of mucopolysaccharides. Efficacy in COPD has been questions. Also used to treat acetaminophen overdose. |
|
|
Term
|
Definition
| Antixidant mucolytic agent, also has anti-inflammatory activity. |
|
|
Term
|
Definition
| Glycoprotein produced in in liver, secreted in blood, diffuses into lung. Inhibits neutrophil elastase (protease inhibitor). Prevents destruction of connective tissue in alveolar walls due to excess neutrophil protease (theory) |
|
|
Term
|
Definition
| Used when chronic severe hypoxemia develops. |
|
|
Term
|
Definition
| Can result in decreased dyspnea and improved sense of well being. Recombinant human deoxyribonuclease. |
|
|
Term
|
Definition
| Supresses cough center in the medula |
|
|
Term
|
Definition
| D-isomer of the codeine analog levorphanol. equieffective to codeine, but non-addivtive tho still subject to abuse. |
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