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Introduction into Endocrinology
pediatrics
28
Medical
Pre-School
10/17/2011

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Term
neurotransmitters
Definition
from axon terminals and into the synaptic junction and act locally
Term
endocrine hormones
Definition
release by glands or specialized cells and circulate in the blood
Term
neuroendocrine hormones
Definition
secreted by neurons and circulate in the blood
Term
paracrines
Definition
secreted by cells into extracellular fluid and affect neighboring target cells
Term
autocrines
Definition
secreted into extracellular fluid and affect the same cells that produce them
Term
cytokines
Definition
peptides secreted into extracellular and function as autocrines, paracrines, or endocrine hormones
Term
What are the three general classes of hormones?
Definition
proteins and polypeptides
steroids
derivatives of the amino acid tyrosine
Term
what hormones are stored in secretory vesicles until needed
Definition
polypeptide and protein hormones
Term
where are polypeptides hormone vesicles stored?
Definition
cytoplast until they fuse with the membrane and their contents are extruded into the blood
Term
what hormones are not acvite until cleaved into prohormones?
Definition
polypeptide and protein hormones
Term
where are amine hormones synthesized and stored?
Definition
thyroid gland
Term
what are amine hormones incorporated into?
Definition
macromolecules of the protein thyroglobulin
Term
after entering the blood, what do most amine hormones combine with?
Definition
plasma proteins
Term
negative feedback prevents....
Definition
over activity of hormone systems
Term
positive feedbacks allow....
Definition
surges of hormones
Term
water soluble hormones are....
Definition
dissolved in the plasma
diffuse out of the capillaries
Term
steroid and thyroid hormones are...
Definition
bound to plasma proteins
biologically inactive until dissociate from plasma proteins
Term
what are two factors of clearance of hormones from the blood?
Definition
rate of hormone secretion into the blood
rate of removal of the hormone from the blood (metabolic clearance rate)
Term
how are hormones cleared?
Definition
metabolic destruction
binding with tissues
excretion by liver into bile
excretion by kidneys into urine
Term
hormones bound to plasma proteins can be there for....
Definition
several hours or days
Term
hormone receptors
Definition
Term
location of the protein peptide hormones
Definition
in or on the surface of the cell membrane
Term
location of steroid hormones
Definition
cell cytoplasm
Term
location of thyroid hormones
Definition
cell nucleus
Term
water soluble proteins circulate freely and are there for how long?
Definition
short time
Term
steroid hormones increase ________
Definition
protein synthesis
Term
thyroid hormones increase ____________
Definition
gene transcription in the cell nucleus
Term
the antibody in radioimmunoassay ____ specific for the hormone.
Definition
highly
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