Term
| Ireverisbly COX 1 and 2 inhib |
|
Definition
| Aspirin by acetylation of active site |
|
|
Term
| Reversible inhib of cox 1 and 2 |
|
Definition
|
|
Term
|
Definition
| indomethacin and sulindac |
|
|
Term
| Cox 2 gene expression blockade |
|
Definition
| NSAIDS in higher conc, and glucocorticoids |
|
|
Term
| Reversible selective Cox 2 inhibitors |
|
Definition
| Nabumetone, and Celecoxib |
|
|
Term
|
Definition
| beclomethasone and flunisolide |
|
|
Term
| Glucocorticoids exert negative fb on hypothal amus resulting in |
|
Definition
inh of CRH rel and thus ACTH release ->
decrease in corticol and atrophy of adrenal cortex
inhib of TRH release and thus TSH: -> result is decr in plasma throxine and hypothyroidism
inhibition of GnRH rel leading to decr in plasma FFSH: ->
resulting in amenorrhea and azoospermia |
|
|
Term
|
Definition
hydrolysis product of sulfasalazine
inhibits both COX-1 and 2 and lipoxygenase |
|
|
Term
| Zafirlukast and Monetlukast |
|
Definition
| block the receptors for LTC4 and LTD4 slow reacting substance of anaphylaxis |
|
|
Term
| Prevents the cyclical ischemia caused by platelet clots |
|
Definition
Aspirin by inhibiting TXA2 production from COX 1 in platelets
TXA2 constricts cardiac arterioles and enhances platelet aggreg. |
|
|
Term
| Prevents and reverses the symptoms of dysmenorrhea |
|
Definition
| ibuprofen by inhib PGE's and PGF2alpha |
|
|
Term
Inhibits parturition
and closes ductus art |
|
Definition
|
|
Term
| does aspirin hypersensitivity have an immunologic component |
|
Definition
| NO, but resembles anaphylactic rxn. arise from enhanced LKtriene synthesis after COX 1 inhibition by aspirin or any other NSAID, except Tylenol |
|
|
Term
| Does Celecoxid and other selective COX-2 inhibotors cause this allergic rxn? |
|
Definition
|
|
Term
| NSAID + Pseudoephedrine = |
|
Definition
|
|
Term
|
Definition
block COX 1 and thus PGEs which are good in kidneys b/c they increase GFR and attenuate ADH thus NSAIDS cause salt/water retention
celecoxibalso has adverse renal effects |
|
|
Term
|
Definition
|
|
Term
| Treatment of GI erosion and ulceration caused by NSAIDS and steroids |
|
Definition
|
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