Term
| How structure affects movement of the drug from point A to point B? |
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Definition
ADME
Absorption
Distribution
Metabolism
Excretion |
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Term
| What is the main organ most drugs have to go through? |
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Definition
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Term
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Definition
| Different compoiunds with the same molecular formula |
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Term
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Definition
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Term
| In order for oxidation to occur, alkanes need what? |
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Definition
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Term
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Definition
Halogenation
Hydrogenation
Oxidation |
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Term
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Definition
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Term
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Definition
| Oxidation occurs on the last Carbon |
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Term
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Definition
| Oxidation occurs on the next to last carbon |
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Term
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Definition
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Definition
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Term
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Definition
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Term
| When oxidized primary alcohols form? |
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Definition
| Aldehydes and Carboxylic Acids |
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Term
| When oxidized secondary alcohols form? |
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Definition
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Term
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Definition
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Definition
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Definition
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Definition
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Term
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Definition
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Term
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Definition
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Term
| When oxidized tertiary alcohols form? |
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Definition
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Term
| Rate dehydration of alcohols from slowest to fastest |
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Definition
| Primary<Secondary<Tertiary |
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Term
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Definition
| double bonds seperated by two single bonds |
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Term
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Definition
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Term
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Definition
| Double bonds seperated by one single bond |
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Term
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Definition
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Term
| Conjugated diene have ____ energy; more _____ |
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Definition
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Term
| Isolated diene has _____ energy; more ____ |
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Definition
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Term
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Definition
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Term
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Definition
| -OH, -OR, -SH, -SR, -NR, -R1, -R2, -R3 |
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Term
| What do electron donating groups do to the aromatic ring? |
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Definition
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Term
| If the R is electron donating, what can occur and where? |
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Definition
Oxidation can occur
It occurs in the para position |
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Term
| Electron Withdrawing Groups |
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Definition
Halogens (F, Br, Cl, I)
COOH, aldehydes, ketones, ester |
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Term
| T or F: Oxidation can occur when the R group is an electron withdrawing group |
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Definition
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Term
| Five Acidic Functional Groups |
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Definition
- Carboxylic Acid
- Sulfonic Acid
- Phosphoric Acid
- Sulfonamide
- Active methylene group
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Definition
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Definition
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Definition
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Term
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Definition
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Term
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Definition
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Term
| What is used to mease the stregth of an acid? |
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Definition
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Term
| Are Amines basic or acidic? |
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Definition
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Term
| T or F: Quaternary amines are not basic |
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Definition
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Term
| Rules to determine if a drug is basic: |
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Definition
- A nitrogen MUST be present
- Is there a strong electorn withdrawing gp attached to N? if yes NOT BASIC
- Does N carry a positive charge? if yes NOT BASIC
- If e's of N contribute to the aromaticity of a ring NOT BASIC
- If N is flanked by two e withdrawing gps NOT BASIC, but H is acidic
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Term
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Definition
| The drug does not contain any acidic grps and basic nitrogens |
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Term
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Definition
| The drug contains both an acidic grp and a basic Nitrogen |
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Term
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Definition
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Term
| How does a drug know where to go? |
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Definition
- Shape of drug
- Affinity for receptor
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Term
| What happens to salt when it is placed in H20? |
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Definition
| Salt will undergo hydrolysis and the solution will becom ebasic |
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Term
| 3 Rxns of Carboxylic Acids |
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Definition
- Ionization
- Neutralization
- Esterfication
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Term
| Esters undergo what type of rxn? |
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Definition
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Term
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Definition
| these are the stereoisomers which are not mirror images |
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Term
| Henderson- Hasselbach Equation |
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Definition
| PH= pKa + Log [cong. base]/[acid] |
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Definition
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Term
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Definition
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Term
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Definition
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Term
| Reduction of azo groups will ALWAYS form ??? |
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Definition
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Term
| When determining the # of stereoisomers what equation would you use? |
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Definition
2n
n= # of chiral centers |
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Term
| Which configuration has coutner-clockwise rotation? |
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Definition
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Term
| Which configuration has clockwise rotation? |
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Definition
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Term
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Definition
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Term
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Definition
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Term
| Equation for % ionization of acids |
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Definition
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Term
| What is the primary purpose for metabolism |
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Definition
| to facilitate elimination from the body |
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Term
| In order for a drug to go thru phase 2 which groups must be present? |
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Definition
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Term
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Definition
| removal of an akyl group from a nitrogen |
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Term
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Definition
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Term
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Definition
Oxidative
Reductive
Hydrolytic |
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Term
| O-Glucuronic Acid Conjugation |
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Definition
| Adding glucuronic acid to an Oxygen |
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Term
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Definition
| Adding sulfur to a functional group |
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Term
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Definition
Adding an amino acid to a functional group
*can only happen on Carboxylic Acid* |
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Term
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Definition
| Adding a methyl group to a sulfur |
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Term
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Definition
Glucuronic Acid Conjugation (O, N, S)
Sulfate Conjugation
Amino Acid Conjugation
Methylation ( O, N, S)
Acetylation
Glutathione Conjugation |
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