Shared Flashcard Set

Details

Intranasal
Final Exam
16
Chemistry
Graduate
12/10/2016

Additional Chemistry Flashcards

 


 

Cards

Term
Intranasal can be used for
Definition
local & sytemic
Term

3 nasal regions (**VRO)

 

Vestibular

 

Respiratory

 

Olfactory

Definition

Vestibular=nasal vestibule & valve

 

Respiratory= extends 6-8cm backwards.inc SA &turbulence

[3 turbinates Inferior,Middle,Superior]

 

Olfactory= Roof of nasal canal

[poorly ventilated, close to CNS. Potential for Rx delivery to brain. Very Small SA]

Term
Which nasal region is major region for rx absorption
Definition
Respiratory Region
Term
Nasal Mucosa 2 parts
Definition

Anterior=1/3 resp region(varying epithelia)

 

 

Posterior=2/3 resp region(gud for abs due to only have 1 cell layer)

[ciliated pseudostratified epithelium,mucociliary clearance]

 

Term

Mucociliary clearance

Mucus

 

 

Cilia

 

Definition

occurs in posterior of resp reg

 

Mucus=protects epi,trap/transports substances(especially rx and undsolved stuff) pH 6.3

 

Cilia= function in coordination ot move mucus[mucus moved posteriorly]

clearanc 15- 20 mins for inhaled sub

Term
one of most important factors physiologically affecting nasal drug absorption
Definition

Mucociliary clearance

[less enzyme act than intestines]

Term
Nasal blood supply is _______ and not drained to _____
Definition

highly vascularized(can absorb large molecules)

 

hepatic portal system

Term
Synarel (Rx)
Definition

Naferelin (generic)[peptide]

for central precocious puberty, nasasl cavity contains fenestrated caps

Term
Nasal associated lymphoid tissue vaccine used intranasal
Definition
Flumist
Term
nasal complicated by these conditions
Definition

Physiologic=rhinitis,asthma,hay fever,nasal polyps

 

environmental=humidity,temp,some rx dry nasal secretion

Term
Dose form design concepts(***POVPD)
Definition

pH=4-8(ciliary beat best at 7-10)

Osmolarity=isotonic liquids preferred

Viscosity = affects drug fate(high slows clearance)

Preservation= Antimicrobial preservatives are usually included in the formulation

dRUG DISPOSITION=form spray vs drop()

Term

Spray=deposited in anterior

 

Drop= generally get greaer coverage 

Definition
sprays=metered dosed aerosol pressurized
Term
SPRAY considerations=
Definition

Description=pressurized aerosol vs mechanical pump

 

Particle size= 8-20 um in diameter impact the nasal cavity

 

Spray bottle design= designed to reach nasal valve

Term

STADOL (Rx)

 

Definition

butorphanol tartrate(generic)

 

nasal spray=used for pain relief(systemic)

extensive first pass

aqueous sol

Term
Rhinocort Nasal Inhaler
Definition

budesonide 

used for allergic rhinitis(local inflammation)

20% reaches sys absorption

metered dosedpressurized inhaler

(micronized budesonide suspended in propellants)

Term
Bactroban Nasal
Definition

Mupirocin calcium

 

ointment 2% nasal colonizaion of MRSA 

Supporting users have an ad free experience!