| Term 
 | Definition 
 
        | undersurface of
 the
 diaphragm
 to
 the
 floor
 of
 the
 pelvis
 containing
 the
 stomach,
 small
 intestine,
 large
 intestine,
 liver,
 gallbladder,
 and
 spleen
 |  | 
        |  | 
        
        | Term 
 | Definition 
 
        | duodenum, pancreas,
 kidneys,
 adrenal
 glands,
 great
 vessels
 (aorta
 and
 vena
 cava),
 and
 most
 mesenteric
 vascular
 structures
 |  | 
        |  | 
        
        | Term 
 | Definition 
 
        | k.a.    spontaneous    bacterial    peritonitis    (SBP);    inflammation    of    the    peritoneum    by    an    extraperitoneal    source,    frequently    occurring    from    hematogenous    dissemination;    no    evident    source |  | 
        |  | 
        
        | Term 
 | Definition 
 
        | inflammation    or    mechanical    break    of    the    integrity    of    the    intestinal    or    the    urogenital    tract    or    solid    organs,    thus    exposing    the    peritoneal    cavity    to    the    resident    GIT    flora       (e.g.    acute    peritonitis    via    perforation,    postoperative    peritonitis,    or    post-‐traumatic    peritonitis) |  | 
        |  | 
        
        | Term 
 | Definition 
 
        | associated    with    highest    morbidity    and    mortality;    persistent    or    recurrent    48    hrs    after intra-‐abdominal    infection,    after    initial    treatment    of    a    primary    or    secondary    peritonitis
 |  | 
        |  | 
        
        | Term 
 
        | Primary  peritonitis  Microbiology |  | Definition 
 
        | often    always    a    monomicrobial    infection    caused    by    enteric    gram    negative    rods |  | 
        |  | 
        
        | Term 
 
        | Secondary  and    tertiary    peritonitis     Microbiology |  | Definition 
 
        | often    a    polymicrobial    infection    caused    by    enteric    gram    negative    rods    and anaerobes
 |  | 
        |  | 
        
        | Term 
 | Definition 
 
        | E coli 
 Escherichia     coli
 Klebsiella     species
 Pseudomonas aeruginosa                                                 14
 Proteus mirabilis
 Enterobacter species
 |  | 
        |  | 
        
        | Term 
 
        | Community-‐Acquired    Empiric    Combination    Therapy    Mild-‐Moderate |  | Definition 
 
        | 1st  generation:    Cefazolin    (IV) 2nd  generation:    Cefuroxime    (IV/PO)
 3rd  generation:    Ceftriaxone    (IV),    Cefotaxime    (IV)
 -‐Plus-‐    Metronidazole    (IV/PO)
 Ciprofloxacin  (IV/PO),    Levofloxacin    (IV/PO)
 -‐Plus-‐    Metronidazole    (IV/PO)
 |  | 
        |  | 
        
        | Term 
 
        | Community-‐Acquired    Empiric    Combination    Therapy Severe |  | Definition 
 
        | 3rd  generation:    Ceftazidime    (IV) 4th  generation:    Cefepime    (IV)
 -‐Plus-‐    Metronidazole    (IV/PO)
 Ciprofloxacin  (IV/PO),    Levofloxacin    (IV/PO)
 -‐Plus-‐    Metronidazole    (IV/PO)
 Gentamicin  (IV),    Tobramycin    (IV),    Amikacin    (IV)
 -‐Plus-‐    Metronidazole    (IV/PO)    or    Clindamycin$(IV/PO)
 Aztreonam  (IV)δ
 -‐Plus-‐    Metronidazole    (IV/PO)
 |  | 
        |  | 
        
        | Term 
 
        | Community  Acquired    Empiric    Monotherapy Mild-‐Moderate |  | Definition 
 
        | Amoxicillin/Clavulanate    (PO)*    Ampicillin/Sulbactam    (IV/PO)*    Ticarcillin/Clavulanate    (IV) 2nd  generation:    Cefoxitin    (IV)γ
 Moxifloxicin  (IV/PO)
 Ertapenem  (IV)
 Tigecycline∝    (IV)
 |  | 
        |  | 
        
        | Term 
 
        | Community  Acquired    Empiric    Monotherapy  Severe |  | Definition 
 
        | Piperacillin/Tazobactam  (IV) -‐
 -‐
 Imipenem/Cilastatin   (IV)    Doripenem    (IV)    Meropenem    (IV)
 -‐
 Aztreonam  (IV)δ
 -‐Plus-‐    Metronidazole    (IV/PO)
 |  | 
        |  | 
        
        | Term 
 | Definition 
 | 
        |  |