Term
| What are the three general findings seen in restrictive interstital lung disease? |
|
Definition
decreased lung compliance
decreased diffusion
decreased lung volumes |
|
|
Term
| What do the acute interstitial lung diseases eventually result in, which is different compared tothe chronic diseases? |
|
Definition
| granulation and not a scar |
|
|
Term
| What are the three acute interstitial lung diseases discussed in this lecture? |
|
Definition
Bronchiolitis Obliterans Organizing Pneumonia
Adult Acute Respiratory Distress Syndrome
Acute iNterstitial Pneumonia |
|
|
Term
| What disease presents with patchy air spaces on XRAY? |
|
Definition
|
|
Term
| Where is the granulation tissue found in the lungs of a patient with bronchiolitis obliterans organizing pneuonia? |
|
Definition
| within the bronchiolar/alveolar lumen |
|
|
Term
| What is the prognosis of BOOP? |
|
Definition
|
|
Term
| What are the pnemoconioses? |
|
Definition
| chronic interstitial lung diseases caused by inhalation of occupational or enviornmental agents |
|
|
Term
| What are the three pnemoconioses discussed in this lecture? |
|
Definition
asbestosis
silicosis
hypersensitivity pneumonitis |
|
|
Term
| What inhaled substance binds to cellular phospholipids and causes death of macrophages? |
|
Definition
|
|
Term
| What are the two types of silicosis? |
|
Definition
Simple Nodular Silicosis
Progressive Massive Silicosis |
|
|
Term
| What disease presents with eggshell calcification? Where is eggshell calcification located? |
|
Definition
Simple nodular silicosis
the eggshell calcification is located around the nodules |
|
|
Term
| How do you generally diagnois silicosis? |
|
Definition
|
|
Term
| Within the nodule of simple nodular silicosis, where is the collagen located? |
|
Definition
| in the center (concentric) |
|
|
Term
| What disease are you predisposed to when you have silicosis? |
|
Definition
|
|
Term
| What is the most common type of interstitial lung disease? |
|
Definition
|
|
Term
| Which asbestos particle is the one that gets into the lungs of patients causing asbestosis? Why? |
|
Definition
| amphabole because it is small and needle like |
|
|
Term
What type of fibrosis is seen in the following:
Silicosis?
Asbestosis?
Hypersenstiivity Pneumonitis? |
|
Definition
Silicosis: nodular fibrosis
Asbestosis: diffuse fibrosis
Hypersenstiivity Pneumonitis: Granulomatous |
|
|
Term
| What are asbestos bodies? |
|
Definition
| a macrophage with a part of the ingested amphabole covered in hemosiderin |
|
|
Term
| Which two categories can hypersensitivity Pneumonitis be broken down to? |
|
Definition
|
|
Term
| Which pneumoconioses causes granulomatous fibrosis? |
|
Definition
| Hypersensitivity pneumonitis |
|
|
Term
| How is chronic hypersensitivity pneumonitis diagnosised? |
|
Definition
|
|
Term
| Which interstitial lung diseases (we talked about 4) can progress to honeycomb lung? |
|
Definition
asbestosis
Hypersensitivity Pneumonitis
usual interstitial pneumonia
sarcoidosis |
|
|
Term
| What type of hypersensitivity is hypersensitivity pneumonitis? |
|
Definition
|
|
Term
| In a lung that has honeycomb lung, what do you want to avoid when taking the biopsy? |
|
Definition
| You want to biopsy a part of the lung w/o honeycomb to assure a smaple of the lung where the disease can be determined |
|
|
Term
| WHat is the second most common interstitial lung disease? |
|
Definition
|
|
Term
| What is the most common idiopathic interstitial lung disease? |
|
Definition
| usual interstitial pneumonia |
|
|
Term
| WHat are the four idiopathic interstitial lung diesease discussed in the lecture? |
|
Definition
usual interstitial pneumonia
desquamative interstitial pneumonitis
respiratory bronchiolitis interstial lung disease
nonspecific interstitial pneumonia |
|
|
Term
| What is true of the age of lesions in usual interstitial pneumonia? |
|
Definition
| they are of different ages |
|
|
Term
| What are the two types of lesions seen in usual interstitial pneumonia at the time of diagnosis? |
|
Definition
honeycomb lesions (late)
lesions w/ fibroblast foci (early) |
|
|
Term
| Which disease presents with a small, stiff, and cobblestone appearling lung? |
|
Definition
| usual interstitial pneumonia |
|
|
Term
| What is the prognosis of usual interstitial pneumonia? |
|
Definition
|
|
Term
| WHere is the honeycombing located in usual interstitial pneumonia? |
|
Definition
|
|
Term
| Which idiopathic interstitial lung disease presents with widespread macrophange involvement and which presents with peribroncholar marcrophage? |
|
Definition
widespread: desquamative interstitial pneumonitis
Peribronchiolar: Respiratory bronchiolitis interstitial lung disease |
|
|
Term
| What are desquamative interstitial pneumonitis and prespiratory bronchiolitis interstitial lung disease closely associated with? |
|
Definition
|
|
Term
| What disease among other organ involvment has both lymph node and lung involvement and is most common in AA women? |
|
Definition
|
|
Term
| Which lymph nodes are involved in sarcodosis? |
|
Definition
|
|
Term
| Which two disease have diffuse interstital reticulonodular infiltrates? |
|
Definition
|
|
Term
| What type of immune T cells are involved in sarcoidosis? |
|
Definition
|
|
Term
| What type of fibrosis occurs in sarcoidosis? |
|
Definition
|
|
Term
| Where is most of the fibrosis found in sarcoidosis? |
|
Definition
|
|
Term
| Why can you do a transbronchial biopsy in sarcoidosis? |
|
Definition
| because the granulomas are located in the submucosa of the bronchioles |
|
|
Term
| What two types of bodies are found in sarcoidosis? |
|
Definition
| schaumann and asteriod bodies |
|
|
Term
| What are schaumann bodies? |
|
Definition
| they are calcium concretions |
|
|
Term
| What must you culture for in a patient suspected to have Sarcoidosis to rule out other disease? |
|
Definition
|
|
Term
| Which interstitial disease is S-100 positive? |
|
Definition
| pulmonary eosinophilic granuloma |
|
|
Term
| Which disease presents with langerhans granuloma cells? |
|
Definition
| Pulmonary eosinophilic granuloma |
|
|
Term
| How can pulmonary eosinophilc granuloma be diagnosised? |
|
Definition
CT
Bronchoalveolar lavage |
|
|
Term
| What is the deficiency in Alveolar proteinosis? |
|
Definition
|
|
Term
| Which disease presents with a crazy paving pattern? |
|
Definition
|
|
Term
| What is the problem in alveolar proteinosis? |
|
Definition
| no GF-CSF so no macrophages to clean up surfactant, so increased surfactant |
|
|
Term
| What type of immune response is good pasture syndrome? |
|
Definition
|
|
Term
| What is the difference between goodpasture syndrome and idiopathic pulmonary hemosiderosis? |
|
Definition
| idiopathic pulmonary hemosiderosis has no kidney involvement |
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