Secreted by macrophages

Causes acute inflammation

Induces chemokine production to recruit leukocytes (activates endothelium to express adhesion molecules)

Endogenous pyrogen

Secreted by Th cells

Stimulates growth of helper and cytotoxic T cells

Secreted by activated T cells

Supports the growth and differentiation of bone marrow stem cells (similar function to GM-CSF)

Secreted by Th2 cells

Promotes growth of B cells

Induces antibody class switching to IgE and IgG

Secreted by Th2 cells

Promotes differentiation of B cells

Enhances class switching to IgA

Stimulates production and activation of eosinophilsI

Secreted by Th cells and macrophages

Stimulates production of acute-phase reactants and immunoglobulins

Overall stimulator of the immune response

Secreted by macrophages

Major chemotactic factor for neutrophils

Secreted by regulatory T cells

Inhibits actions of activated T cells

Activates Th2, inhibits Th1 and macrophages

Secreted by B cells and macrophages

Activates NK and Th1 cells

Secreted by Th1 cells

Stinmulates macrophages

Activates Th1, inhibits Th2

Secreted by macrophages

Mediates septic shock

Causes leukocyte recruitement and vascular leak