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| Secreted by macrophages and tissue cells; α and β subunits are inflammatory cytokines that promote inflammation and the inflammatory response (fever, lethargy, anorexia, increased permeability of the vasculature) and activate lymphocytes |
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| Secreted by dendritic cells, antigen stimulated T-cells, and NK cells; stimulates growth of CD4 and CD8 T-cells; activated T cells express high affinity for IL-2; activates B-cells and NK cells; approved for treatment of renal cell carcinoma and melanoma |
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| Stimulates Th2 response and suppresses Th1 response; stimulates the production of IgE; stimulates the creation of memory B-cells during T-cell dependent activation |
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| Secretion is stimulated by the TH2 response; secreted by CD4 T-cells; stimulates production of IgA; recruits eosinophils from the bone marrow and activates them; also a growth factor for basophils along with interleukin 3 |
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| Secreted by macrophages; stimulates liver to secrete CRP, MBL, and fibrinogen; induces fat and muscle cells to metabolize to increase body temperature |
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| Produced by fibroblasts and bone marrow stromal cells; necessary for the proliferation of immature lymphoid progenitors |
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| Stimulates B-cell maturation during T-cell dependent activation; causes the B-cell to mature into a plasma cell; no pro-inflammatory activity |
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| Secreted by macrophages; attracts natural killer cells and causes them to proliferate and secrete IFNγ; stimulates Th1 CD4 T-cells; also secreted by dendritic cells to activate T-cells and by antigen presenting cells to activate CD8 T-cells |
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| Stimulated by the TH2 response; secreted by basophils; induces epithelial cell repair and mucus secretion |
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| Stimulates the survival and proliferation of memory CD4 and CD8 T cells; also secreted by macrophages when they are bound to natural killer cells answers to further activate natural killer cells in close proximity |
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| Secreted by TH17 cells and follicular helper T cells; attracts neutrophils |
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| Secreted by TH9 cells and differentiates some T cells into T(fh) cells |
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| Secreted by TH17 cells and TH22 cells |
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Definition
| Inhibits T(fh) cells and stimulates TH17 cells |
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| Inhibitory cytokine secreted by Tregs |
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| Growth factor for basophils |
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| Secreted by mast cells with granules; attracts monocytes, macrophages and neutrophils |
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| aka Eotaxin; stmulates the migration of eosinophils into tissues |
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| Secreted by dendritic cells; attracts immature B-cells to lymph node |
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| Secreted by stromal and dendritic cells in the T-cell area of lymph node; attracts immature B-cells |
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| Secreted by monocytes, macrophages, B-cells, natural killer cells, and infected cells; induces an antiviral state in uninfected cells and activates natural killer cells |
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| Secreted by infected cells activates in case else and induces antiviral state in neighboring uninfected cells |
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| Secreted by T-cells and natural killer cells; activates macrophages; activates Th1 response and suppresses Th2 response; stimulates MHC Class I and II expression |
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| Induces production of IgG2b and IgA and inhibits production of IgM and IgG3 |
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| A G-coupled protein secreted by macrophages that recruits neutrophils from HEVs; also increased integrin avidity |
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| Secreted by follicular dendritic cells |
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