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Integumentary System
Lecture 7
140
Pathology
Graduate
07/08/2014

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Cards

Term
Primary lesion examples
Definition
tumor, blister, papule, wheal
Term
Secondary lesion examples
Definition
irritation of primary lesion, medication, healing, natural disease progression
Term
pruritis
Definition
itching
Term
diseases that often lead to pruritis
Definition
diabetes, hyperthyroidism, drug hypersenstivity
Term
dangers of pruritis
Definition
scratching injuries resulting in breakdown of protective barrier
Term
urticaria
Definition
hives
Term
a vascular reaction of the skin which results in appearance of a smooth, elevated areas of the skin
Definition
urticaria
Term
What may urticaria be accompanied by
Definition
pruritis
Term
How can urticaria be causes
Definition
allergic response to a drug or medication
Term
How long does urticaria usually last
Definition
usually <2 days, can be chronic lasting months or years
Term
generalized eruption of the skin usually of the face, trunk, axilla, and the groin which may range from simple erythema to a raised popular appearance
Definition
rash
Term
A rash usually occurs as a result of exposure to
Definition
sun, allergen, irritant or medicaiton
Term
Butterfly-shaped rash across the face is typically indicative of
Definition
lupus
Term
elevated skin lesions containing clear, watery, or bloody fluid
Definition
blisters
Term
Blisters are associated with what
Definition
genetic/autoimmune disorders, viral/bacterial infections, local skin injuries, drug induced
Term
skin dryness characterized by dry, rough, discolored skin with scaly desquamation. Sometimes coupled with hyperpigmentation
Definition
xeroderma
Term
desqaumation
Definition
peeling
Term
This disorder is more prevalent in certain climates or with exposure to certain chemicals
Definition
xeroderma
Term
Puberty Skin Changes: Maturation of...
Definition
hair follicles, sebaceous glands, sweat glands
Term
Maturation of hair follicles, sebaceous glands, sweat glands may lead to what during puberty
Definition
acne, perspiration, body odor, freckles, moles
Term
Skin changes during adulthood
Definition
change in hair growth patterns, hyperpigmentation in the face
Term
What abnormalities may result in increased facial and body hair growth in women, and in men baldness
Definition
hormonal
Term
Many of these age=related changes are accelerated by what
Definition
smoking and sun exposure
Term
senescence
Definition
old age
Term
Graying of the hair, balding, skin laxity, vascular changes, loss of elasticity, wrinkling
Definition
old age related skin changes
Term
Degenerative changes in the skin
Definition
loss of elastin fibers in the skin, weakening of collagen, diminished subcutaneous fat
Term
How is contact dermatitis caused
Definition
chemical, mechanical, physical, biologic agent
Term
Common triggers of contact dermatitis
Definition
nickel, chromates, wool fats, rubber and latex additives, topical antibiotics, anesthetics, silicone
Term
What symptoms begin within 24-48 hours with contact dermatitis
Definition
pruritis, erythema, edema
Term
What other symptoms may progress in regards to contact dermatitis
Definition
oozing blisters with watery discharge, crusting, scaling
Term
Contact Dermatitis PTI: Patient focus
Definition
assess patient's skin prior to and after the use of any substance
Term
Contact Dermatitis PTI: Cautions
Definition
when using products potentially containing silicone, various creams/oils, latex, or adhesives
Term
How is stasis dermatitis caused?
Definition
edema in the leg forms as a result of immobility and compromised venous return
Term
Edema which causes stasis dermatitis leads to what
Definition
slowing of venous return and hypoxia and necrosis
Term
Stasis dermatitis: Clinical Picture
Definition
pruritis, heaviness in the leg, brown-stained skin, open lesions and wounds which are very slow to heal
Term
Stasis Dermatitis: PTII
Definition
exercise, compressive garments, gait training
Term
How do skin infections usually occur
Definition
hospitalization
Term
Skin infections may be caused by
Definition
bacteria, viruses, fungi
Term
Risk factors for skin infections
Definition
decresaed immune resistance, dehydrated skin, burns, pressure ulcers, decresased blood flow, poor hygiene, overcrowded living conditions
Term
inflammation of the dermis and the subcutaneous tissue caused by infection of the skin by either the Strep or Staph bacteria
Definition
cellulitis
Term
What are other predisposing factors for cellulitis
Definition
leg edema, cutaneous wounds
Term
lymphangitis
Definition
infection of nearby lymph vessels
Term
how is lymphangitis identified by
Definition
appearance of red streaks extending from the original reddened area
Term
cellulitis clinical picture
Definition
skin redness, swelling, tenderness, lymphangitis
Term
herpes zoster
Definition
shingles
Term
VZV
Definition
varicella zoster virus
Term
A dormant VZV is ______ multiple times thoguht the lifespan but it is usually _____ from antibiotics to the initial infection
Definition
reactivated, neutralized
Term
In the case of an immunocompromised individual, the virus multiplies where
Definition
nerves' ganglia
Term
Shingles multiply in the nerve's ganglia results in what
Definition
destruction of the host neuron, spreading down the sensory nerves to the skin
Term
How is herpes zoster usually identified
Definition
unilateral formation of blisters along the dermatome of the affected nerve
Term
Herpes zoster involves the trunk or in the distribution of which nerve
Definition
trigeminal, CN#5
Term
neuralgia
Definition
nerve pain
Term
3 groups of skin cancers
Definition
benign, malignant, premalignant
Term
What triggers Malignant Melanoma
Definition
UV damaging DNA inside the nucleus of the epidermal cells
Term
UV damaging DNA inside of the epidermal cells causes what to happen
Definition
enzymatic repair of DNA
Term
If the DNA is not repaired properly what happens
Definition
further damage and cell death
Term
Sun exposure can cause malignancy, meaning what
Definition
replication of damaged, mutated melanocytes
Term
Malignant Melanoma: PTI
Definition
refer to doctor, dermatologist, ABCD
Term
A
Definition
asymmetry
Term
B
Definition
border
Term
C
Definition
color
Term
d
Definition
diameter
Term
asymmetry
Definition
most beningn moles are symmetrical
Term
border
Definition
poorly defined edges may indicate malignancy
Term
color
Definition
changes in color can indicate malignancy
Term
diamter
Definition
benign moles tend not to be larger than a pencil's eraser
Term
a chronic inherited recurrent inflammatory dermatosis characterized by well-defined red plaques covered with a silvery scale
Definition
psoriasis
Term
The life cycle of skin's keratinocyte is approximately what
Definition
28 days
Term
Keratinocytes form where
Definition
lower epidermis
Term
How long does it take keratinocytes to move superficiallly from the lower epidermis to the stratum corneum
Definition
14 days
Term
Once the keratinocytes reach the stratum corneum, how long do they typically live
Definition
14 days
Term
What happens to keratinocytes after 28 days
Definition
sloughed off from wear and tear
Term
How long is the turnover time of keratinocyes with psoriasis
Definition
3-4 days
Term
What does the short turn over time of the keratinocytes mean
Definition
cells never reach maturity
Term
WIth the keratonicytes never reaching maturity, what do they do
Definition
stick together and build up in the skin
Term
Immature Keratinocytes sticking together results in what
Definition
flaky and thick stratum corneum
Term
What is another theory for the occurence of psoriasis
Definition
immune system dysfunction
Term
Psoriasis clinical picture
Definition
reddened papules, blisters, plaques covered with a silvery scale
Term
Where does psoriasis usually affect
Definition
scalp, chest, nails, elbows, knees, groin, skin fold, low back, buttocks
Term
10% of those with psoriasis develop this
Definition
psoriatic arthritis
Term
Psoriasis PTI
Definition
education on steroid creams, relaxation and stress management, UVR lamps in the clinic
Term
Widespread small vessel vasculopathy and fibrosis
Definition
scleroderma
Term
What happens during scleroderma: 1
Definition
relentless depositon of collagen in the blood vessels, percapillary space, skin's interstitum
Term
What happens during scleroderma: 2
Definition
deposition of collagen results in endothelial injury, microvascular lesions, thickening of vascular walls of all organs involved, including skin
Term
What happens during scleroderma: 3
Definition
autonomic nerve dysfunction followins in gastrointestinal and cardiovascular systems
Term
What happens during scleroderma: 4
Definition
altered vascular function leads to increased vasospasm, decreased vasodilation capacity, increased adhesiveness of blood vessels to platelets and lymphocytes
Term
How many stages are there to scleroderma
Definition
3
Term
Sclero Derma Stage 1
Definition
edematous stage
Term
Edematous stage
Definition
bilateral ptting edma is present in hands>feet
Term
After several weeks to months of chronic edema, the edema is replaced by what
Definition
thick, hard skin
Term
Stage 2 scleroderma
Definition
sclerotic stage
Term
Sclerotic stage
Definition
skin becomes tight, smooth, waxy and appears to adhere to underlying tissue
Term
loss of skin folds, especially in the fact, decreased flexibility and changes in the skin's pigment
Definition
sclerotic stage changes
Term
stage 3 scleroderma
Definition
atrophic stage
Term
atrophic stage
Definition
skin atrophies especially at the site of flexion contractures
Term
atrophic stage dangers
Definition
thinning of the skin may lead to cutaneous ulcerations
Term
Other manifestations of scleroderma: raynauds
Definition
vasoconstriction of the extremities blood vessels leading to blanching, cyanosis, erythema
Term
Scleroderma NM manifestations
Definition
disuse atrophy
Term
What therapy to try for scleroderma
Definition
aquatic therapy
Term
Why try aquatic therapy for scleroderma NM manifestations
Definition
unweight joints, decrease pain, increase joint motions
Term
Scleroderma, visceral manifestations
Definition
decreased mobility due to scarring may inpepded normal function of organs/tissues
Term
Hypothermia risk factors
Definition
lack of body fat, old age, homelessness, substance abuse, cardiac disease, pscyhiatric disease, smoking
Term
At what tissue temperature do ice crystals form
Definition
-2 C
Term
What happens when ice crystals form in the tissues
Definition
localized cold-related injuris including cell compression and rupture of cell membranes
Term
Upon warming and thawing of tissues what happesn
Definition
capillary permeability increases, histamine is released, microvessels can be occluded
Term
if microvessels are occluded what happens
Definition
oxygen and nutrients cannot be delivered leading to potential tissue death
Term
Hypothermia PTI
Definition
application of cold modalities should be done carefully
Term
Partial burns
Definition
affect the dermis
Term
full thickness burns
Definition
affect the subcutaneous tissue
Term
What is the Rule of (s
Definition
method for figuring burn size
Term
BSA Children
Definition
Head=Chest=Back>Leg>Arms
Term
BSA Adult
Definition
Front=Back=Leg=Leg>arm, arm, head,
Term
Types of burns
Definition
thermal, chemical, electrical, radiation
Term
A systemic effect is seen with burns that involve what percentage of TBSA
Definition
>25%
Term
Burns: CV CHanges: 1
Definition
increased capillary permeability
Term
Burns: CV CHanges: 2
Definition
generalized edema
Term
Burns: CV CHanges: 3
Definition
decreased intravascular blood volume, hypovolema, increased heart rate, decreased cardiac output
Term
Burns: CV CHanges: 4
Definition
IV fluids to replenish blood volume, avoid hypovolemia, shock, death
Term
Burns: Renal and GI changes
Definition
loss of blood volume in extensive burns, >25%, leads to renal and intestine dysfunction
Term
Burns: Respiratory
Definition
pulmonary artery hypertension and decreased lung compliance, Atelectasis can occur
Term
Burns immune system
Definition
overall system is depressed which increases risk of life-threnitening infection and sepsis
Term
Burns clinical picture
Definition
depends on depth, extent, location of the burn
Term
Partial thickness burn
Definition
affects dermis, large painful blisters, discoloration, edema, shiny weeping skin surfaces
Term
How long does a superficial partial thickness burn take to heal
Definition
2-3 weeks to heal
Term
how long does a deeper partial thickness burn take to heal
Definition
3-4 weeks
Term
Why is there an elevated risk of infection with burns?
Definition
blistering and disruption of the skin
Term
Full thickness burns are characterized by what
Definition
deep discoloration, dry surfaces, edema, exposed fat
Term
Full thickness burns have a potential for what
Definition
hypertrophic scarring and contracture
Term
How long will it take a full thickness burn to heal
Definition
weeks to months with possible skin grafts needed
Term
BURNS PTI
Definition
splinting and positioning to avoid contractures
Term
Burns other PTI
Definition
deep breathing, promote wound heailng, assist with functional mobility, watch for potential medical complications, monitor vital signs, talk with patient, inspect wounds
Term
Breakdown of the skin, and possibly subcutaneous tissue, caused by unrelenting pressure
Definition
pressure sores
Term
where are pressure sores more common?
Definition
heels, elbows, sacrum, greater trochanters
Term
How many stages of pressure sores are there
Definition
4
Term
Which stage is the worst for a pressure ulcer
Definition
4
Term
Pressure Sores pathophys: 1
Definition
continuous pressure compresses capillaries and occludes blood flow
Term
Pressure Sores pathophys: 2
Definition
tearing or shearing of blood vessels may also occur with movement of the skin layers in opposite directions
Term
Pressure Sores pathophys: 3
Definition
plately aggregation occurs causing thrombi, occluding blood flow, and causing necrosis of tissue. Elvates risk of bacterial invasion and infection
Term
How often should a patient with no volitional movement and those that are incontinent be repositioned?
Definition
every 2 hours
Term
Pressure Sores PTI
Definition
keep patient, clean, dry, monitor for S/S, positioning
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