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innunohistochemical stains
immunohistochemical stains
43
Other
Professional
05/24/2016

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Term
distinguish btw BBC from trichoepithelioma
Definition
BCL-2
negativly regulates programmed cell death
Term
pagets disease
expressed in eccrine and apocrine epithelium
Definition
CEA ( carcinoembryonic antigen )
Term
spindle cell squamous cell carcinoma
distinguishing primary carcinoma of the skin from metastatic carcinoma
Definition
CK 5\6
cytokeratin - expressed in basal layer of stratified squamous epithelia
Term
expressed in eccrine and apocrine epithelium
pagets disease
cutaneous metastases of breast
Definition
CK 7
low molecular weight cytokeratin
Term
metastatic transitional cell carcinoma
merkel cell carcinoma
Definition
CK 20
Term
most sebaceous glands\often stains malignant eccrine and apocrine tumors
Definition
EMA - epithelial membrane antigen
high molecular weight transmembrane glycoprotein expressed in many epithelial cells
Term
breast carcinoma
sweat gland carcinoma with apocrine differentiation
Definition
GCDFP - 15
Term
actinic keratoses\squamous cell carcinoma in situ \ invasive squamous cell carcinoma
Definition
P53
Term
spindle cell squamous cell carcinoma
undifferentiated carcinoma
adnexal carcinoma
Definition
PP63
Term
melanocytic nevi and melanoma
Definition
HMB45
glycoprotein present in premelanosomes and melanosomes
Term
melanocytic nevi and melanomas( highly specific )
PECOMAS
Definition
MART-1\MILAN A
Term
melanocytic nevi and melanoma
Definition
MITF-1 ( microphthalmia associated transcription facto )
Term
Melanocytic nevi and spitz nevi
strong nuclear and cytoplasmic expression may favor benignity in melanocytic processes
Definition
P16
Term
neurotropic melanoma when S100 staining is weak or absent
Definition
P75
Term
most sensitive marker for melanoma and spindle cell desmoplastic melanoma
Definition
S100
Term
sensitivity decreases with increased clinical stage and metastasis
Definition
tyrosinase
Term
merkel cell carcinoma
Definition
chromogranin
Term
most sensitive stain for Merkel cell ca
Definition
CK20
Term
merkel cell carcinoma
neural tumors
Definition
1.neurofilament
2.synaptophysin
Term
thyroid ca.
small cell lung ca
visceral neuroendocrine tumors
merkel cell ca.
Definition
TTF-1 ( can be used in combination with CK20 when aiming for nerkel cell carcinoma )
Term
smooth muscle neoplasm
Definition
caldesmon
Term
dermatofibroma
renal cell ca
neurothekeoma
Definition
CD10
Term
ewing sarcoma
peripheral neuroectodermal tumor
Definition
CD99 (MIC2)
Term
smooth and striated muscle neoplasms
Definition
desmin
Term
all mesenchymal cells\tumors, sarcomatoid carcinoma
Definition
vimentin
Term
kaposi sarcoma
Definition
HHV 8
Podoplanin ( D2-40 )
Term
benign and malignant vascular neoplasm
Definition
CD31
Term
langerhans cell histiocytosis
T cell lymphoblastic lymphoma
Definition
CD1a
Term
Blastic NK cells lymphoma, myeloid leikemia, soft tissue tumores
NON langerhans cell histopcytosis
Definition
CD68
Term
langerhans cell histiocytosis
Definition
CD207( langerin )
S100
Term
Mastocytosis, myeloid leukemia
gastrointestinal stromal tumors
Definition
CD117 ( c-KIT )
Term
Mastocytosis
Definition
tryptase
Term
Diffuse B-cell lymphima
follicular lymphomas
Definition
bcl-2
Term
T cell lymphoma
Definition
CD3
CD4
CD5
CD7
CD8
Term
B cell lymphoma\leukemia
Definition
CD5
CD8
CD10
CD20
Term
CLASSIC HODGKIN DISEASE
acute myeloid leukemia
Definition
CD15 ( leuM1 , lewis X )
Term
most B and T cell lymphomas
Definition
CD45
CD43
Term
B cell lymphoma
Definition
CD20
Term
T cell lymphoma
Definition
CD45RO
Term
B cell lymphoma ( may be positive in cases where CD20 is negative
plasma cell neoplasm
Definition
CD79a
Term
Cytotoxic t cell lymphoma
Definition
granzyme B
perforin
TIA 1
Term
mycobacterial infections\mycotic infections\bacterial infections
Definition
BCG
Term
assesment of proliferative activity of tumors ( with malignancy generally possessing an elevated profilerative index)
Definition
KI-67
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