Term
| distinguish btw BBC from trichoepithelioma |
|
Definition
BCL-2
negativly regulates programmed cell death |
|
|
Term
pagets disease
expressed in eccrine and apocrine epithelium |
|
Definition
| CEA ( carcinoembryonic antigen ) |
|
|
Term
spindle cell squamous cell carcinoma
distinguishing primary carcinoma of the skin from metastatic carcinoma |
|
Definition
CK 5\6
cytokeratin - expressed in basal layer of stratified squamous epithelia |
|
|
Term
expressed in eccrine and apocrine epithelium
pagets disease
cutaneous metastases of breast |
|
Definition
CK 7
low molecular weight cytokeratin |
|
|
Term
metastatic transitional cell carcinoma
merkel cell carcinoma |
|
Definition
|
|
Term
| most sebaceous glands\often stains malignant eccrine and apocrine tumors |
|
Definition
EMA - epithelial membrane antigen
high molecular weight transmembrane glycoprotein expressed in many epithelial cells |
|
|
Term
breast carcinoma
sweat gland carcinoma with apocrine differentiation |
|
Definition
|
|
Term
| actinic keratoses\squamous cell carcinoma in situ \ invasive squamous cell carcinoma |
|
Definition
|
|
Term
spindle cell squamous cell carcinoma
undifferentiated carcinoma
adnexal carcinoma |
|
Definition
|
|
Term
| melanocytic nevi and melanoma |
|
Definition
HMB45
glycoprotein present in premelanosomes and melanosomes |
|
|
Term
melanocytic nevi and melanomas( highly specific )
PECOMAS |
|
Definition
|
|
Term
| melanocytic nevi and melanoma |
|
Definition
| MITF-1 ( microphthalmia associated transcription facto ) |
|
|
Term
Melanocytic nevi and spitz nevi
strong nuclear and cytoplasmic expression may favor benignity in melanocytic processes |
|
Definition
|
|
Term
| neurotropic melanoma when S100 staining is weak or absent |
|
Definition
|
|
Term
| most sensitive marker for melanoma and spindle cell desmoplastic melanoma |
|
Definition
|
|
Term
| sensitivity decreases with increased clinical stage and metastasis |
|
Definition
|
|
Term
|
Definition
|
|
Term
| most sensitive stain for Merkel cell ca |
|
Definition
|
|
Term
merkel cell carcinoma
neural tumors |
|
Definition
1.neurofilament
2.synaptophysin |
|
|
Term
thyroid ca.
small cell lung ca
visceral neuroendocrine tumors
merkel cell ca. |
|
Definition
| TTF-1 ( can be used in combination with CK20 when aiming for nerkel cell carcinoma ) |
|
|
Term
|
Definition
|
|
Term
dermatofibroma
renal cell ca
neurothekeoma |
|
Definition
|
|
Term
ewing sarcoma
peripheral neuroectodermal tumor |
|
Definition
|
|
Term
| smooth and striated muscle neoplasms |
|
Definition
|
|
Term
| all mesenchymal cells\tumors, sarcomatoid carcinoma |
|
Definition
|
|
Term
|
Definition
HHV 8
Podoplanin ( D2-40 ) |
|
|
Term
| benign and malignant vascular neoplasm |
|
Definition
|
|
Term
langerhans cell histiocytosis
T cell lymphoblastic lymphoma |
|
Definition
|
|
Term
Blastic NK cells lymphoma, myeloid leikemia, soft tissue tumores
NON langerhans cell histopcytosis |
|
Definition
|
|
Term
| langerhans cell histiocytosis |
|
Definition
|
|
Term
Mastocytosis, myeloid leukemia
gastrointestinal stromal tumors |
|
Definition
|
|
Term
|
Definition
|
|
Term
Diffuse B-cell lymphima
follicular lymphomas |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
CLASSIC HODGKIN DISEASE
acute myeloid leukemia |
|
Definition
|
|
Term
| most B and T cell lymphomas |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
B cell lymphoma ( may be positive in cases where CD20 is negative
plasma cell neoplasm |
|
Definition
|
|
Term
| Cytotoxic t cell lymphoma |
|
Definition
|
|
Term
| mycobacterial infections\mycotic infections\bacterial infections |
|
Definition
|
|
Term
| assesment of proliferative activity of tumors ( with malignancy generally possessing an elevated profilerative index) |
|
Definition
|
|
