Term
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Definition
(PMN – polymorphonuclear leukocytes)
Phagocytic
Migrate to damaged/infected areas in blood
Granulocyte |
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Definition
Anti-parasitic
Limit inflammatory response
Granulocyte |
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Definition
Inflammatory response
Granulocyte |
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Definition
Agranulocytes
Specific immune response
Two general types
T cells: responsible for cell mediated immunity
B cells: responsible for humoral response
Agranulocytes |
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Term
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Definition
Immature: leave blood and differentiate into macrophages or dendritic cells
Agranulocytes |
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Definition
Inflammatory response
Widely distributed |
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Definition
Phagocytic
Involved in specific immunity and other responses |
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Term
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Definition
Involved in specific immunity.
from monocytes |
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Term
| Natural Killer (NK) Cells |
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Definition
NK cells destroy your cells if they loose their MHC class I proteins.
perforin and granzymes |
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Term
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Definition
Major histocompatibility complex I
When do cells loose MHC class I molecules?
Some malignant cells.
Result of some intracellular infections. |
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Term
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Definition
| System of vein-like vessels that return fluid that leaks from blood capillaries back to the circulatory system |
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Term
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Definition
vessels expansions filled with lymphocytes and macrophages
respond to foreign cells, molecules, etc in lymph |
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Definition
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Definition
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Definition
| Skin Associated Lymphatic Tissue |
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Definition
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Definition
Neutrophils (PMNs)
Macrophages
(Dendritic cells) |
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Term
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Definition
built by your cells.
Antibodies
Activated complement proteins |
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Term
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Definition
pathogen-associated molecular patterns
Membrane protein receptors of phagocyte bind to these target molecules:
LPS, Peptidoglycan, etc
Results in Phagocytosis or Production and expression of cytokines |
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Term
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Definition
Toll-Like Receptors
Receptor proteins of phagocytes that bind to PAMPs. |
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Term
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Definition
taken into phagosome.
Killed and Digested
Reactive Oxygen compounds
H2O2, O2-, etc
Chemicals and enzymes in lysosomes. |
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Term
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Definition
| After phagocytosis, fragments of digested molecules attached to MHC (I and II) proteins and displayed on surface |
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Term
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Definition
| Antigen Antibody complexes activate C1, which splits C2 and C4 into C2a, C2b, C4a and C4b. C2a and C4b bind together and activate C3. |
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Term
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Definition
mannose binding lectin
secreted from liver as a result of activated macrophages
binds to carbohydrate (mannose) found in many bacterial cell walls and the envelopes of some viruses
bound lectin splits C2 and C4 into C2a, C2b, C4a and C4b. C2a and C4b bind together and activate C3. |
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Term
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Definition
Cytokine secreted by viral infected cells
Stimulate production of AVPs (antiviral proteins) in nearby cells
Inhibits replication of viral nucleic acids in these cells |
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Term
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Definition
Antimicrobial Peptides:
produced by host cells in response to contact with certain microbial chemicals
Inhibit cell wall synthesis
Enhance inflammation
Counteract LPS |
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Term
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Definition
Lipopolysaccharides
act as endotoxins |
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Definition
Iron Binding Proteins
blood and tissue fluids
Cytokines from macrophages increase their production during infection. |
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Definition
Iron Binding Proteins
milk, saliva, mucus
Cytokines from macrophages increase their production during infection. |
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Term
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Definition
C5b+C6+C7+C8+C9= Membrane attack complex!
perforates cell membrane |
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Term
| opsonization (Complement) |
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Definition
C3b
Enhancement of phagocytosis by coating with C3b,
near by cytolysis |
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Term
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Definition
C5a, C3a
Mast cells and/or basophils release histamine,
Blood vessel permeability increases + chemotaxic attraction of phagocytes
redness, swelling, pain, heat
chemicals that stimulate pain receptors
leukotrienes – attract phagocytes (chemotaxis) |
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Term
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Definition
| C3 combines with B, D, and P factors on microbe, which makes C3 split |
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Definition
Inflamation mechanism:
vasodilation increases blood flow to area
Increased delivery of leukocytes and chemical factors that inhibit infection.
Clotting factors, complement, etc.
heating
inhibit microbes and more efficient defenses
edema (swelling)
More fluid into lymphatic vessels |
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