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| Biochemical barriers of first line of defense |
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Definition
| Epithelial surfaces provide biochemical as well as physical barriers to trap and destroy pathogens, include epithelial derived chemicals and bacteria derived chemicals |
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| Epithelial derived chemicals |
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Definition
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| Antimicrobial peptides that disrupt the cell membrane of the bacteria, alpha and beta |
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| Begins immediately after cell injury or infection. May result in resolution and healing or progress into chronic inflammation |
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| Can destroy pathogens directly and are among the body's most potent defenders against bacterial infection. Accomplished in three ways - lectin, classical and alternative pathway |
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| Activated by proteins of the acquired immune system (antibodies) bound to specific targets (antigens) |
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| Activated by certain bacterial carbohydrates |
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| Activated by gram bacterial and fungal cell wall polysaccharides |
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| Molecules that tag pathogenic microorganisms for destruction by cells of inflammation (neutrophils and macrophages) |
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| Efficient opsonin in complement system |
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| Biochemical substance that attracts leukocytes to site of inflammation |
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| Four functions of complement system |
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Definition
Opsonisation
Anaphylatoxic activity resulting in mast cell degranulation
Leukocyte chemotaxis
Cell lysis |
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Term
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Definition
| Forms a fibrinous meshwork at an injured or inflamed site that prevents the spread of infection, keeps microorganisms and foregin bodies at the site of greatest inflammatory cell activity, provides a framework for repair and healing |
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