Term
|
Definition
Vasoconstriction followed by vasodilatation (Flooding)
Increase hydrostatic pressure (Load)
Slow circulation- viscosity, stasis (Onerous)
Permeability (Weeping) |
|
|
Term
|
Definition
Rubor = redness
Tumor = swelling
Calor = heat
Dolor = pain
(described by Celsus 1st. Century AD)
Functio laesa = loss of function
(added by R. Virchow) |
|
|
Term
|
Definition
Flowing
Leukoycte recruitment
adhesion
migraiton
mopping up |
|
|
Term
|
Definition
| rolling. integrina ctivation by chemokines. (E selectin and P selectin), stabel adhesion migration through endothelium. |
|
|
Term
|
Definition
Passive Through endothelial gaps Diapedesis
Active PECAM Degradation of BM and ECM
6-24 hrs Polymorphs
24-48hrs Monocytes, lymphocytes |
|
|
Term
type of cell for acute
type of cell for chronic |
|
Definition
Acute inflammation = neutorphil
Chronic inflammation = lymph |
|
|
Term
| chemotaxis agents used for leuokcyte migration |
|
Definition
Chemoattractants
Exogenous - Bacterial products
Endogenous - C5a, LTB4, IL-8 |
|
|
Term
|
Definition
Opsonization
Phagocytosis
Ping!
Oxygen dependent (free radicals)
Oxygen independent (enzymes |
|
|
Term
| important mediators in response |
|
Definition
Inflamation: il 1, and TNF alpha impt for
IL2 and IFN = impt in immunology(t/ cell and b cell shelping each other.)
IL12: impt for thelp
IL4, 5, as helper T ell type 2.
KNOW THIS! |
|
|
Term
| reason of severe left shift in immune reponse--> granulocytosis |
|
Definition
Leukocyte release results from a direct effect of IL-1 and IL-6 on bone marrow neutrophil stores.
Exaggeration of this can result in a “Leukemoid reaction” release of very immature precursors and cel |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
Serous
Catarrhal
Fibrinous
Hemorrhagic
Suppurative
Gangrenous
Pseudomembranous |
|
|
Term
|
Definition
| vascular permeability, larger molecules such as fibrinogen pass the vascular barrier, and fibrin is formed and deposited in the extracellular spac |
|
|
Term
|
Definition
| production of large amounts of pus or purulent exudate consisting of neutrophils, necrotic cells, and edema fluid. |
|
|
Term
|
Definition
| Loss or destruction of epithelial. |
|
|
Term
|
Definition
| . Significant destruction of vesel walls. Sever vascularities can have hemmoragin manifestion w/ inflammation fo veslle wall |
|
|
Term
|
Definition
| more necrosis than inflammation |
|
|
Term
| termination of inflammation |
|
Definition
Eradication of an offending agent
Neutrophils have only a short life span (few hours -1 day)
Most mediators are very short lived
Anti-inflammatory cytokines (TGF-beta, and IL-10) can inhibit the production of pro-inflammatory cytokines (TNF)
Arachidonic acid metabolites - lipoxin and resolvins - have anti-inflammatory activity
Exact mechanism elusive |
|
|
Term
|
Definition
The proliferation of blood vessels, granulomas, tissue fibrosis and tissue necrosis.
Lymphocytes and macrophages. |
|
|
Term
|
Definition
short vs long
neturophils /macrophages (acute)
lymphocytes, plasma cells, macrophages, fibroblasts (chronic)
very little changes in perphipheral blood in chronic. neutrophils presnt in acute. |
|
|
Term
| what does granuloma form around? |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| inflition of neutorphils intratubula aggregate s of enturophils tubular necorsis. itssue look dusty lue pink |
|
|
Term
|
Definition
presented with increasing headache and throbbing temporal pain. Associated symptoms include fever, and generalized muscle aching.
want to give steroid immediately. arteries are narrowed by intimal fibrosis
2/3 cases get giant cell |
|
|
Term
|
Definition
grade fever, weight loss, and night sweats
Granulomas
Caseating necrosis: b/c of lots of
Mycloic acid. |
|
|
Term
|
Definition
| complains frequently of burning, gnawing, epigastric pain about 1-3 hours after his "two martini" lunches. Sometimes the pain awakens him at night. |
|
|
Term
|
Definition
intermittent attacks of chronic diarrhea and rectal bleeding that persists for days to sometimes weeks. These episodes have been recurrent over several years.
effects mucosa and submucos
Acute cryptitis
Cryptal abscess
Inflammation
Crypt architecture distortion |
|
|
