Term
| protective mechanisms such as external barriers and bodily secretions are commposed of what type of immunity? |
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Definition
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Term
| the key cells involved in developing adaptive or acquired immunity are? |
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Definition
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Term
| the immunologic principles involved with the ability of a vaccine to prevent disease is? |
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Definition
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Term
| the immunoglobulin responsible for defense against infection during the first few weeks of life is? |
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Definition
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Term
| the first immunoglobulin to respond to infection is? |
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Definition
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Term
| the immunoglobulin involved in allergic reactions is? |
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Definition
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Term
| the migration of neutrophils or polymorphonuclear leukocytes (PMNs) to the site of an invading microbe is referred to as? |
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Definition
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Term
| heparin, histamine, and serotonin, which intensify inflammation are released by ? |
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Definition
| basophils release heparin, histimine and serotonin |
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Term
| lymphocytes that are effectors of cell-mediated immunity are? |
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Definition
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Term
| T cells mature in what organ |
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Definition
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Term
| Immune complex reactions are categorized into what type of hypersensitivity? |
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Definition
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Term
| the bacterial pathogens most often associated with destructive perio make up what color complex |
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Definition
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Term
| the primary pro-inflammatory cytokine is? |
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Definition
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Term
| the T cell predominates in what stage of periodontal disease? |
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Definition
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Term
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Definition
| a complex body defense system what protects the body from bacterial, viral, fungal, toxins and parasites |
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Term
what is involved in 1st line of defense
NONSPECIFIC RESISTANCE |
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Definition
intact skin
mucous membranes
normal microbes |
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Term
what is involved in second line of defense?
NONSPECIFIC RESISTANCE |
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Definition
phagocytes, white blood cells, inflammation
fever
antimicrobial substances |
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Term
Third line of defense
SPECIFIC RESISTANCE |
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Definition
specialized lymphocytes B cells and T cells
anitbodies |
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Term
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Definition
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Term
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Definition
| specific antibody and lymphocyte response to antigen |
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Term
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Definition
| substance that causes body to produce certain antibodies or sensitized T cells |
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Term
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Definition
| proteins made in response to antigen |
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Term
| Differential white cell count |
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Definition
| % of each type of white cell in a sample of 100 blood cells |
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
1st line of defense
lysosomes bacteriocidal and digestive enzymes that kills and digests bacteria |
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Term
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Definition
largest lymphocytes
slow to arrive
kidney shaped |
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Term
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Definition
memory and plasma be cells
most effective against bacteria
from bone marrow
transform into plasma
PRODUCE ANTIBODIES!!!!!
secrete antibodies into blood stream, neutrolize bacteria, coat it for phagocytosis, activate compliment system. |
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Term
| what is the protein response to antigens? |
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Definition
immunoglobulins
glycoprotiens
antibodies
produced by b cells
5 major groups |
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Term
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Definition
1st to the scene
large
remains in blood does not migrate through tissue
initiates complement cascade |
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Term
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Definition
second on the scene lasts longest
opsonization-coats antigen for destruction
prepares with killer cells
activates the compliment cascade |
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Term
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Definition
trace antibody
thought to activate b cells
initiation of immune response |
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Term
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Definition
| tears, saliva, secretions, bile and respiratory excretions |
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Term
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Definition
binds to mast cells and basophils
stimulates release of histimines, seratonin and heparin in allergic reaction.
intensifies response of b cells and macrophages |
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Term
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Definition
cellular immunity
against virus, cancer fungi
produce cytokines
from bone marrow to thymus
memory
cytoxic targets virus and tumors
delayed inflammation with allergic reaction |
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Term
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Definition
| a series of enzymes that continually circulate in blood to assist with phagocytosis of bacteria by bodies and antibodies. |
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Term
| components of complement system |
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Definition
membrane attack complex
opsonization-coating
recruitment of additional phagocytes
clean up |
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Term
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Definition
transendothelial migration
rolling
activation
adhesion
protrusion
transmigration |
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Term
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Definition
biologically active compounds that are released by the immune cells to activeat body's inflammatory response
biochemical mediators-middle men |
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Term
| what are some examples of inflammatory mediators? |
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Definition
cytokines-activate immune response
chemokines-sub group of cytokines
prostaglandins
matrix metalloproteinases |
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Term
| what are some sources of cytokines |
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Definition
pmn
macrophage
b cell
epithelial cell
fibroblasts
osteoblasts |
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Term
| what are some examples of cytokines |
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Definition
| interleukin-1, interluekin -6, interleukin-8, tumor necrosis factor TFN-a |
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Term
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Definition
recruit cells
increase vascular permeability
increase cell movement
initiate tissue destruction and bone loss
chemical messenger between white blood cells |
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Term
| what prostoglandin is a major mediator of bone loss |
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Definition
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Term
| what is the type of prostoglandin that increases vascular permeability and vasodilation and also triggers osteoclasts. |
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Definition
prostoglandin E.
it is also a major mediator of alveolar bone loss!!!! |
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Term
| what are the sources of matrix metalloproteinases? |
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Definition
-macrophages
-gingival fibroblasts
-JE cells
-PMNs
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Term
| what are the affects on Matrix metalloproteinases? |
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Definition
health-normal tissue turnover
disease- produced to kill invaders
overproduction- break down of CT
collagen destruction-by way of collagenase, protenase, and elastase |
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Term
| what are the stages of page and shroeders periodontal progression? |
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Definition
-Stage I 2-4 days Initial/Subclinical stage
-Stage II 4-7 days Early gingivitisPlaque overgrowth/early lesion stage
-Stage III 2-3 weeks, subgingival plaque stage, established lesion.
-Stage IV, tissue destruction periodontitis, advanced lesion |
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Term
| what stage of page and shroeders perio progression stimulates osteoclasts by way of prosteglandin E? |
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Definition
| tissue destruction phase/ perio/ advanced lesion |
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