Term
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Definition
Primitive response = phagocytosis,hypertrophy/hyperplasia
- inflammation - reaction of blood vessels
- Repair |
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Term
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Definition
What happens when a local response can't maintain a infection
-Whole body is affected |
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Term
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Definition
-Direct injury
- Damage-associated molecular pattern (DAMPs)
- Pathogen-associated molecular patterns (PAMPs) |
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Definition
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Definition
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Term
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Definition
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Definition
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Term
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Definition
| inflammation of the liver |
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Term
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Definition
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Term
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Definition
-inflammation dominated by vascular changes, accompanied by neurtophilis
-minutes/days
-plasma, neutrophils |
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Term
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Definition
- happens when initial doesn't fix the problem
-uses mature/fibrous tissue to form a scar
-weeks
-Fibrous tissue, macrophages, lymphocytes, plasma cells |
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Term
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Definition
| -red (hyperemia), swelling, heat (calor), pain(dolor), loss of function |
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Term
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Definition
-Neutralize the stimulus/agent
-prepare for repair
-essential for healing of that area
-get plasma from the blood to increase healing process |
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Term
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Definition
life threatening to critical organs (lungs, brain)
-Cause damage by itself |
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Term
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Definition
Vascular phase
Cellular phase
Reparitive phase |
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Term
| Vascular Phase (Plasma & Vascular phase) |
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Definition
Plasma, flows into tissue through gaps (leukotrienes)
Endothelial cells contract becoming smaller, gaps between them open up
Vasodilation opens capillaries increasing blood flow, circulation decreases due to increased permeability
-Stasis develops, leukocytes migrate out of vessel |
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Term
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Definition
-leukocytes emigrate to tissues
-leukocyte activation,
-phagocytosis
-release of leukocyte products |
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Term
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Definition
| direct leukocytes to an area of injury, increase concentration of an enticing smell |
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Term
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Definition
Connective tissue cells and components
fibroblasts |
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Term
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Definition
Specific
Symptomatic
Cost Benefit Analysis
R.I.C.E |
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Term
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Definition
remove the cause
e.x remove splinter from finger |
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Term
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Definition
makes you feel better until it heals itself
e.x pain killers |
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Term
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Definition
| Beneficial effect v.s Adverse reaction |
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Term
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Definition
| rest, ice, compression, elevation |
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Term
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Definition
Targets for pharmaceuticals
originate from plasma or cells
Many act through receptors
Many cause release of other mediators
Most are short lived
Most may have harmful effects |
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Term
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Definition
| vasodilation and increase permeability |
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Term
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Definition
dilates arterioles (vasodilation)
increase permeability of venules
-produced by mast cells |
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Term
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Definition
Block receptors
-Drying
-Sedation |
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Term
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Definition
-Reduce blood flow
-vasoconstriction (increase air flow in nose)
-Steroids
-Non steroidal |
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Term
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Definition
| reduce side effects of inflammation by reducing blood flow |
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Term
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Definition
substances similar to what is produced by our own adrenal glands
-Very effective (very potent)
-reduce your ability to fight infection |
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Term
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Definition
original was aspirin (anti inflammatory drug)
-same effects as steroids without adverse side effects |
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Term
| Cell membrane phospholipids |
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Definition
| -Phospholipase A (breakdown cell membranes): Arachidonic Acid broke down in to Leukotrienes by lipoxygenase or Prostaglandins (important mediators of inflammation) by Cyclooxygenase |
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Term
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Definition
| Maintains blood flow to kidney, stomach, and intestine |
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Term
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Definition
Cocaine, Procaine, Lidocaine
-menthol (local anesthetic)
- salicylic acid (part of the aspirin group) |
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Term
| Pain - systemic analgesics |
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Definition
Narcotics: heroin, morphine, opium
Non-narcotics: tylenol, NSAIDS |
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Term
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Definition
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Term
| Systemic Effect: Acute Phase Response |
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Definition
| Fever, shivering, leucocytosis(dead tissue is removed), acute phase protein release |
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Term
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Definition
Cytokines
Chemokines
pro/anti-inflammatory cytokines |
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Term
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Definition
After Initial Phase
Repeated bouts of inflammation
Insidious smouldering reaction |
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Term
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Definition
neutrophilic
Eosinophilic
Lymphocytic plasmacytic
Histiocytic and granulomatous |
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Definition
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Term
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Definition
| allergic hypersensitivity |
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Term
| Granulomatous Inflammation |
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Definition
bacteria, fungi, inorganic substances
-Dominated by marcophages w/lymphocytes |
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Term
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Definition
monocytes have single nucleus & no prominent granules, go into tissue and reside
-activated T cells produce lymphokines, influence monocytes to activate macrophages
-T cell recognize antigens and fight disease w/ macrophages |
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