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Inflammation and Arthritic Disease
Test 2
28
Pharmacology
Professional
02/21/2010

Additional Pharmacology Flashcards

 


 

Cards

Term
Alprostadil
Definition
Synthetic PGE1 used to maintain patency of ductus arteriousus
Term
PGE and PGI2 effects (lung)
Definition
dilate bronchioles (TXA2 constricts)
Term
PGE and PGI2 effects (Cardiovascular)
Definition
Dilate coronary vessels and decrease BP
Term
TXA2 (Cardiovascular)
Definition
^ BP, constricts coronary vessels, and causes platelet aggregation
Term
PGE and PGI2 effects (GI)
Definition
Inhibit gastric acid and pepsin, increase mucous secretions (protective)
Term
Misoprostrol
Definition
PGE1 analog used to promote ulcer healing (inhibit gastric acid and pepsin w/ ^ mucous)
Term
PGE2 (repoductive system)
Definition
Relaxes non-pregnant uterus (contracts pregnant)
Term
PGF2alpha effects (Reproductive)
Definition
-Contracts pregnant and non-pregnant uterus
-causes corpus luteum to lyse
Term
PGE2 and PGF2 (as treatment)
Definition
Used to induce abortion and to control post-partum hemorrhage
Term
Dinoprostone
Definition
Facilitates labor by ripening and dilating cervix
Term
Zafirlukast
Definition
Block actions of leukotrienes (inflammation, bronchoconstriction, chemotaxis) used to treat asthma
Term
Montelukast
Definition
Block actions of leukotrienes (inflammation, bronchoconstriction, chemotaxis) used to treat asthma
Term
Aspirin
Definition
-Can worsen gout at low doses
@therapeutic doses stimulate respiration
@toxic doses depresses respiration and displaces bicarb (true metabolic acidosis)
-Don't use in 3rd trimester of pregnancy
Term
Acetaminophen
Definition
-Not a good anti-inflammatory
Good use for pts with: ulcers, blood thinners, clottind disorders, gout
**OD can cause fatal hepatic necrosis
Term
N-Acetylcysteine
Definition
Tx for overdose of Acetaminophen
Term
Celecoxib
Definition
COX2 inhibitor (selective so it doesn't mess with homestatic properties of COX1)
Contra: Sulfa sensitivity
Sfx: Increase cardiovascular risk
Term
Azathioprine
Definition
Tx: Severe rheumatoid arthritis unresponsive to conventional treatment
-antineoplastic drugs
Term
Indomethacin
Definition
NSAID
-High anti-inflammatory
-high toxicity
Term
Methotrexate
Definition
Tx: Severe rheumatoid arthritis unresponsive to conventional treatment
-Suppresses immunesystem
Term
Naproxen
Definition
NSAID
-Twice a day dosing
Term
Etanercept
Definition
Anti-Rheumatic
Binds TNFa (false receptor) and prevents it from interacting w/ receptors
Sfx: Infection, contraindicated in sepsis
Term
Infliximab
Definition
Anti-rheumatic
ab to TNFa
*Can cause lupus-like syndrome
Term
Abatacept
Definition
Anti-rheumatic
-Fusion protein that binds CD4 rendering T-cells inactive
Term
Ibuprofen
Definition
NSAID
-Less GI effects
Term
Colchicine
Definition
Anti-Gout (useful in relief of attacks)
-Blocks migration of granulocytes to area
-Not uricosuric
Term
Probenecid
Definition
Anti-Gout
-Increase excretion by decreasing reabsorption (have to drink a lot of water)
Term
Sulfinpyrazone
Definition
Anti-Gout
-Increase excretion by decreasing reabsorption (have to drink a lot of water)
Term
Allopurinol
Definition
Anti-gout
Inhibits xanthine oxidase (reduces production of uric acid)
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