common side effects of glycopeptide antibiotics

follow blood level drug concentration )

glycopeptide  

*remember has a lipid tail

in combo with other drugs for treatment of TB

monoth for treatment of latent TB

in combo for nontuberculous mycobacterial (less frequent)

analog of nicotinamide, 

complex mode of action, best definited as inhibition of mycolic acid biosynthesis

bactericidal but less active against fast growing cells

low in general

peripheral neuropathy and CNS toxicity

protein biosynthesis

interacts with 50S

synercid. work synergistically to block polypeptide translation by 50S subunit.

modifications improve water solubility and have allowed clinical approval for treatment of VRE infections

aminoglycoside antibiotic

primariliy used for gram negative bacteria

*bactericidal action and synergy with other antibiotics such as betalactams

works best on gram negative but good for gram positive with the new generations

SE generally well tolerated, CNS toxicity( nalidixic acid worse) GI irritation