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Infections of the CNS
CNS
37
Microbiology
Undergraduate 2
04/18/2012

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Term
CNS pathogens
Definition
normal flora (N. meningitidis, H. influenzae, S. pneumoniae)
L. monocytogenes (ingestion)
Group B streptococcus (birthing process)
Staphylococcus species (shunts)
Term
Chronic Meningitis
Definition
M. tuberculosis, fungi, protozoans
symptoms develop over weeks
Term
aseptic meningitis (Viral)
Definition
absence of culturable bacteria/fungi
inflammation, self-limiting, cleared eventually
herpes virus
polio virus
mumps
Term
purulent meningitis
Definition
purulent exudate
bacterial
Term
encephalitis
(inflammation of neurons, no signs)
Definition
rabies
polio
measles
herpes simplex
paralysis
defective mental capacities
Term
dangers of CNS infection
Definition
intracranial pressure
biochemical abnormalities
neural tissue necrosis
edema
Term
hypoxia
Definition
Term
Tetanus
(Clostridium tetani)
Definition
exotoxins-affinity for CNS tissue
antibiotic ineffective after exotoxin produced
Term
botulism
(Clostridium botulinum)
Definition
no signs at first
cranial nerve palsy
symmetrical paralysis descending
respiratory muscle paralysis
Term
foodborne botulism
(cns & intoxication)
Definition
toxin absorbed- intestinal tract
reaches NMJ -via bloodstream
binds to and inhibits release of Acetylcholine
muscular paralysis
Term
botulism
(2 additional)
Definition
wound form-rare
infant form-(honey)
Term
Botulism
(treatment)
Definition
anti-toxin
mechanical ventilation
antibiotic
Term
Rabies
(pathogen)
Definition
bullet-shaped
covered glycoproteins
negative-RNA
affect all mammals
Term
Rabies
(2 forms)
Definition
urban- unimmunized cats/dogs
sylvatic- wild animals
Term
rabies
(acute fatal encephalitis)
Definition
transmitted via infected saliva of a bite from infected animal
(incubation period 10days-1year
Term
Most dangerous results of CNS infection
Definition
vasogenic edema-
swelling brain-albumin entering CSF
Term
Which can infect CNS?
Definition
Neisseria meningitidis
Listeria monocytogenes
Streptococcus pneumoniae
Haemophilus influenzae
Term
Infections of CNS can result from...
Definition
middle ear infection
sinusitis
mastoiditis
pneumonia
Term
The clinical features of CNS infection includes
Definition
aseptic meningitis
encephalitis
poliomyelitis
polyneuritis (paralysis of muscles)
Term
clinical effects of botulism are caused by
Definition
exotoxins
Term
antibiotic therapy for tetanus would be
Definition
effective only if given early in infection
Term
the symptoms of infant botulism
Definition
constipation
Term
rabies virus transmitted via
Definition
saliva of infected animal
Term
symptoms of rabies include
Definition
headache
nausea
lethargy
vomiting
NOT HALLUCINATIONS
Term
POLIO VIRUS binds to receptors on
Definition
motor neurons
Term
prions are
Definition
proteins
Term
Most dangerous results of CNS infection
Definition
vasogenic edema-
swelling brain-albumin entering CSF
Term
Which can infect CNS?
Definition
Neisseria meningitidis
Listeria monocytogenes
Streptococcus pneumoniae
Haemophilus influenzae
Term
Infections of CNS can result from...
Definition
middle ear infection
sinusitis
mastoiditis
pneumonia
Term
The clinical features of CNS infection includes
Definition
aseptic meningitis
encephalitis
poliomyelitis
polyneuritis (paralysis of muscles)
Term
clinical effects of botulism are caused by
Definition
exotoxins
Term
antibiotic therapy for tetanus would be
Definition
effective only if given early in infection
Term
the symptoms of infant botulism
Definition
constipation
Term
rabies virus transmitted via
Definition
saliva of infected animal
Term
symptoms of rabies include
Definition
headache
nausea
lethargy
vomiting
NOT HALLUCINATIONS
Term
POLIO VIRUS binds to receptors on
Definition
motor neurons
Term
prions are
Definition
proteins
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