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Infection Lecture
applied patho
31
Other
Graduate
10/04/2008

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Term
Systemic signs of infectious disease
Definition
fever, chills, malaise, lymphadenopathy
Term
Integumentary signs of infectious disease
Definition
purulent drainage, rash, red streaks, bleeding gums or joint space bleeding, erythema of joints with effusion
Term
Cardiovascular signs of infectious disease
Definition
petechiae (small areas of hemorrhage), tachycardia/bradycardia, hypotension
Term
CNS signs of infectious disease
Definition
altered mental state, headache, photophobia (sensitivity to light), memory loss, stiff neck, myalgia
Term
GI signs of infectious disease
Definition
nausea, vomiting, diarrhea
Term
Genitourinary signs of infectious disease
Definition
dysuria or flank pain, hematuria, oliguria (small urine output), urgency/frequency
Term
Upper respiratory system signs of infectious disease
Definition
cough, hoarseness, sore throat, nasal drainage, sputum production
Term
Common causes of prolonged fever of 102 degrees F or lower
Definition
atelectasis, phlebitis, dehydration, pulmonary emboli, pancreatitis, MI, malignancy, hepatitis, mono, TB
Term
Common causes of prolonged fever of 104 degrees F or higher
Definition
transfusion rxns, IV line sepsis, HIV infections, drug fever, lymphoma, heat stroke, urosepsis, metastatic cancer of liver or CNS
Term
Signs and symptoms of infection in the immune compromised
Definition
tachypnea, confusion, hypotension
Term
Rash definition
Definition
local rxn due to penetration of statum corneum by microorganisms
Term
Impact of aging on infectious disease
Definition
lack fever and common signs and symptoms, change in mental status (confusion, lethargy), diminished cell mediated immunity with reactivation of dormant infections, influenza deaths common, skin atrophy, achlorhydria (less stomach acid produced), decreased couh and gag reflex and mucociliary activity, decreased hygiene, dexterity, mobility, and vision
Term
Definition of infection
Definition
process in which an organism establishes a parasitic relationship with the host
Term
Definition of transmission
Definition
movement of organism from environment, vector, or another host to a new host
Term
Definition of colonization
Definition
the successful transmission, invasion and replication of the pathogen in the host with the development of clinically silent, asymptomatic or subclinical disease states
Term
Definition of incubation period
Definition
the variable time period from when the pathogen first enters the host until an evident disease state is reached
Term
Definition of latent infection
Definition
the microorganism has penetrated and replicated, but remains inactive in the host
Term
Definition of the period of communicability
Definition
the time when the organism is present in sufficient number to be shed and passed to others which may precede symptoms and continue through part or all of the clinical disease state and into convalescence (aka infectious period)
Term
Definition of carrier
Definition
individual capable of transmitting the disease to others without having symptoms of the disease themselves
Term
Definition of communicable disease
Definition
the pathogen may be passed or carried from one person to another directly or indirectly
Term
Mycoplasmata
Definition
bacteria lacking cell walls (have cell membranes instead), host cell dependent
Term
Chain of transmission
Definition
pathogen to reservoir to portal of exit to mode of transmission to portal of entry to susceptible host
Term
Characteristics of pathogens leading to disease
Definition
infectivity, pathogenicity, virulence, toxigenicity, antigenicity
Term
Definition of reservoirs
Definition
environment where organisma can live and multiply at specific stages of the organisms' life cycle
Term
Definition of portal of exit
Definition
how the parasite leaves reservoirs usually corresponds to the site of entry into the host (ex. feces, fluids)
Term
Types of modes of transmission
Definition
contact, airborn, enteric, vector bourne (mosquitoes and WNV and fomites), nosocomial infections
Term
Methods of portal of entry
Definition
ingestion, inhalation, bites, contact with mucus membranes, percutaenous or transplacentally
Term
Factors of host susceptibility
Definition
age, sex, ethnicity, life styles, health and nutritional status, hormonal balance, presence of concurrent disease, integrity of host defense mechanisms and barriers
Term
1st line of defense
Definition
skin (oil and sweat), mucus membranes, cilia, gag and cough reflex, peristalsis in GI tract, flushing action of tears, saliva, and mucus, pH of body fluids, normal flora
Term
2nd line of defense
Definition
inflammatory processes and local rxns, wall off/destroy/neutralize pathogens, can become chronic with destruction of healthy tissue
Term
3rd line of defense
Definition
immune response, specific response to specific antigen (antibody formation)
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