Term
| 6 Diseases to use TMP-SMX (trim/sulfa) for |
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Definition
Acute uncomplicated UTI
Prostatitis
Travelers & shigella diarrhea
Nocardia
Listeria (if can't use penicillin)
Pneumocystis jiroveci pneumonia
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Term
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Definition
a. selectively inhibit dihydropteroate synthase, which does synthesis of dihydrofolic acid
b. competitively inhibit incorporation of PABA |
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Term
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Definition
| selectively blocks folate reduction by dihydrofolate reductase in bacteria |
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Term
| Who have the worst adverse reactions to TMP-SMX? |
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Definition
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Term
| 4 Adverse reactions to TMP-SMX |
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Definition
| wierd skin/mucosal rashes, GI upset, bad in pregnancy, bad in G-6-PD deficiency |
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Term
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Definition
| binds 50S ribosomal subunit and blocks translocation to stop prot. synthesis |
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Term
| Diseases Clindamycin is used in (2) |
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Definition
- Anaerobic infections
- for really bad strep skin infection |
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Term
| Main adverse reaction to Clindamycin |
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Definition
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Term
| What type of diseases Metronidazole is used for |
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Definition
| Anaerobes and protozoans (parasites) |
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Term
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Definition
| undergoes a reaction catalyzed by pyruvate:ferredoxin oxidoreductase and makes free radicals to kill bacteria and protozoa |
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Term
| 3 Adverse reactions to Metronidazole |
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Definition
Metallic taste
dark urine
Disulfram-reaction w/ alcohol |
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Term
| Diseases Chloramphenicol is used for |
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Definition
| Meningitis or resistant organisms (or in 3rd world countries b/c it's cheap- causes gray baby syndrome and anemia) |
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Term
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Definition
| reversibly binds to 50S ribosomal subunit to inhibit protein synthesis |
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Term
| Chloramphenicol is antagonistic to what other antibiotic? |
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Definition
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